Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues.

Archives of Pathology & Laboratory Medicine
William B Laskin, Markku Miettinen

Abstract

Transmembrane adhesion molecules, epithelial-type cadherin (ECAD) and neural-type cadherin (NCAD), help in regulating transformations between epithelial and mesenchymal cells in the developing embryo and in maintaining the epithelioid phenotype. Consequently, the presence of epithelioid cells in certain malignant noncarcinomatous neoplasms raises speculation that the expression of ECAD and NCAD in these neoplasms may have diagnostic significance. To investigate the utility of ECAD and NCAD immunoexpression in distinguishing malignant (noncarcinomatous) neoplasms with epithelioid features that involve the soft tissues. Membranous immunoreactivity of anti-ECAD and anti-NCAD was evaluated on archived cases selected from the files of the Armed Forces Institute of Pathology. Epithelial-type cadherin was found in biphasic synovial sarcoma (35 of 35 cases), malignant melanoma (13/21), monophasic fibrous synovial sarcoma (13/26), clear cell sarcoma (4/9), poorly differentiated synovial sarcoma (3/13), diffuse mesothelioma (4/20), malignant epithelioid peripheral nerve sheath tumor (1/6), and epithelioid sarcoma (5/62). Neural-type cadherin was observed in chordoma (11/11), biphasic synovial sarcoma (30/35), diffuse mesothelioma (14/20)...Continue Reading

References

Sep 1, 1991·Pathology, Research and Practice·I DardickS P Hammar
Mar 1, 1994·The Journal of Pathology·M Guarino, L Christensen
Jan 1, 1996·The American Journal of Surgical Pathology·E GaertnerW D Travis
Jan 1, 1995·Acta Anatomica·J L DubandD Newgreen
Jun 1, 1996·The Journal of Pathology·G P Cowley, M E Smith
May 1, 1997·Developmental Biology·M George-WeinsteinK A Knudsen
Mar 1, 1997·Cell Adhesion and Communication·R B HazanP I Borgen
Aug 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S M Frisch
Aug 1, 1997·Histopathology·M E Smith, M Pignatelli
Dec 8, 1998·International Journal of Cancer. Journal International Du Cancer·D S SandersJ Jankowski
Jul 10, 1999·Pathology, Research and Practice·M GuarinoF Giordano

❮ Previous
Next ❯

Citations

Feb 8, 2007·Archives of Pathology & Laboratory Medicine·Andrea T Deyrup, Anthony G Montag
Dec 10, 2015·Advances in Anatomic Pathology·Khin ThwayCyril Fisher
Aug 30, 2003·Archives of Pathology & Laboratory Medicine·William B Laskin, Markku Miettinen
May 11, 2021·The Spine Journal : Official Journal of the North American Spine Society·Zach PenningtonDaniel M Sciubba
Jan 6, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Steven D BillingsAndrew L Folpe
Aug 28, 2004·Histopathology·C FisherS W Weiss
Jul 13, 2005·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Aly G Saad, Margaret H Collins
Oct 15, 2005·The American Journal of Surgical Pathology·Aymara TrianaRachel Hazan
Oct 26, 2005·Virchows Archiv : an International Journal of Pathology·R AwasthiM E F Smith
Dec 6, 2005·Pathology, Research and Practice·Marcello GuarinoAntonella Tosoni
Jun 17, 2006·Advances in Anatomic Pathology·Cyril Fisher
Sep 16, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mark D MurpheyDonald A Gajewski
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Justin M M CatesCandice C Black
Jun 27, 2006·Pathology Oncology Research : POR·Eszter SzékelyImre Romics
Dec 6, 2005·Histopathology·M E F SmithC Fisher
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Rita AlaggioSara O Vargas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.