PMID: 9557712Apr 29, 1998Paper

Epithelial uptake and transport of cell-free human immunodeficiency virus type 1 and gp120-coated microparticles

Journal of Virology
A KageG Pauli

Abstract

Cell-free human immunodeficiency virus type 1 (HIV-1) can be taken up and released by a monolayer of primary human gingival cells and remain infectious for CD4+ cells. Virus-sized latex particles covalently coated with purified native HIV-1 envelope glycoprotein gp120 are also transported through the primary epithelial cells. This process is significantly stimulated by increasing the intracellular cyclic AMP (cAMP) concentration. Inhibition experiments with mannan and alpha-methyl-mannopyranoside indicated that mannosyl groups are involved in the interaction between gp120 and gingival cells. An increase of cellular oligomannosyl receptors by incubation with the mannosidase inhibitor deoxymannojirimycin augmented transcellular transport of the gp120-coated particles. The results suggest that infectious HIV can penetrate gingival epithelia by a cAMP-dependent transport mechanism involving interaction of the lectin-like domain of gp120 and mannosyl residues on glycoproteins on the mucosal surface. Penetration of HIV could be inhibited by soluble glycoconjugates present in oral mucins.

References

Nov 1, 1987·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·H GelderblomG Pauli
Dec 1, 1989·The Journal of Cell Biology·M BomselK Simons
Nov 1, 1987·Archives of Biochemistry and Biophysics·R E LoomisP C Jones
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L CordellD Y Mason
Jan 1, 1995·AIDS Research and Human Retroviruses·L HammarJ C Chermann
Jun 1, 1995·The Journal of General Virology·B LudewigG Pauli

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Citations

Jun 19, 2013·Immunological Reviews·Lianna F WoodDonald L Sodora
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Grigorios FotopoulosJean-Pierre Kraehenbuhl
Jan 15, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Grace John-StewartUNKNOWN Ghent IAS Working Group on HIV in Women Children
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caren J ChanceyRichard B Markham
May 5, 2006·Advances in Dental Research·M C HerzbergS M Wahl

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