Epithelially derived endothelin and nitric oxide in asthma

International Archives of Allergy and Immunology
P H HowarthS T Holgate

Abstract

Immunohistochemical staining of endobronchial biopsies has identified increased expression of the 21-amino-acid peptide endothelin (ET) and the inducible form of the enzyme nitric oxide synthase (iNOS) within the airway epithelium in asthma. Elevated concentrations of ET are also recovered in bronchoalveolar lavage fluid from asthma patients. iNOS generates the gas nitric oxide from L-arginine, and elevated levels of NO in exhaled air have been described in asthma. ET is a potent bronchoconstrictor and levels of ET in lavage and resting airflow obstruction are correlated. The effects of ET on bronchomotor tone may be modified by NO as this is a bronchodilator. The relative balance between ET and NOS may thus contribute to resting bronchomotor tone. ET also stimulates fibroblast proliferation, collagen gene expression and through its inhibitory actions on collagenase will promote airway wall collagen deposition and contributes to airway wall thickening which underlies bronchial hyperresponsiveness. The regulation of these epithelial events may thus be important to the control of asthma.

Citations

Mar 29, 2002·Pediatric Pulmonology·Niranjan KissoonPhilip E Silkoff
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Gary HellermannShyam S Mohapatra
Jan 1, 1997·Research in Immunology·D B Jacoby
Feb 8, 2000·The International Journal of Biochemistry & Cell Biology·M J BoscoeM H Yacoub
Apr 6, 2011·The Journal of Experimental Medicine·Charles PerkinsFred D Finkelman
Aug 31, 2000·Pediatric Emergency Care·L R DeNicolaP E Silkoff
Jan 6, 2012·Journal of Allergy·Annaïg OzierPatrick Berger
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·P J FranklinS M Stick
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·P R MillsJ L Devalia
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·N KissoonP E Silkoff
Dec 26, 2001·American Journal of Respiratory Cell and Molecular Biology·Louise E Donnelly, Peter J Barnes
Sep 2, 2015·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Sonoko HaradaKazuhisa Takahashi
Oct 8, 2008·Peptides·Talia Filipovich, Sigal Fleisher-Berkovich
Nov 25, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·David W ReidE Haydn Walters
Jan 22, 2008·Nature Reviews. Immunology·Patrick G HoltFrode L Jahnsen
Apr 4, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K ChibanaH W Chu
Jan 30, 1999·Medicine and Science in Sports and Exercise·K C Beck
Mar 21, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·K YamauchiH Inoue
May 5, 2021·Advanced Biology·Sarah L BarronRóisín M Owens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
F H GuoS C Erzurum
British Journal of Industrial Medicine
P B Cook
Archives of Disease in Childhood
B Zoritch
© 2021 Meta ULC. All rights reserved