Epithelioid Hemangioma (Angiolymphoid Hyperplasia With Eosinophilia) of the Heart With Peripheral Eosinophilia and Nephrotic Syndrome

International Journal of Surgical Pathology
Isidro MachadoAntonio Llombart-Bosch

Abstract

Epithelioid hemangioma (EH) is a rare benign vascular lesion, characterized by endothelial cells with epithelioid/histiocytoid appearance. Heart involvement is extremely rare. We present an unusual case of cardiac EH in a young woman with supraventricular arrhythmia, nephrotic syndrome (membranous glomerulopathy), and peripheral eosinophilia after a pregnancy and normal partum resembling Kimura disease. Echocardiogram showed a large tumor mass in the right cardiac ventricle. The cardiac tumor was removed and the histopathology revealed an endothelial proliferation associated with abundant eosinophils. The neoplastic endothelial cells were eosinophilic and polygonal with epithelioid/histiocytoid morphology. Lymphoid nodules were occasionally seen. The neoplastic cells were positive for CD34, CD31, ERG, and factor VIII and negative for CK. A diagnosis of EH was rendered. The patient was alive and well after surgical resection. EH and Kimura disease represent separate entities, but clinical and/or histological overlapping can be observed. Epithelioid/histiocytoid endothelial cells constitute the hallmark feature that favors a final diagnosis of EH.

References

Dec 1, 1992·Journal of the American Academy of Dermatology·S I Chun, H G Ji
Sep 1, 1990·Yonsei Medical Journal·H J Ahn, K G Lee
Oct 1, 1987·The American Journal of Surgical Pathology·A UrabeM Enjoji
May 1, 1985·Journal of the American Academy of Dermatology·T G Olsen, E B Helwig
Apr 6, 2005·International Journal of Dermatology·Maryam AzizzadehFatemeh Sari-Aslani
Aug 27, 2005·Archives of Pathology & Laboratory Medicine·Neda Zarrin-KhamehRuc M Tran
Sep 17, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·P HolloA Horvath
Jun 27, 2007·Journal of Medical Case Reports·Bruno F FernandesMiguel N Burnier
Jul 22, 2009·European Journal of Dermatology : EJD·Rieko KabashimaYoshiki Tokura
Sep 7, 2011·Annales de dermatologie et de vénéréologie·U Sass
Nov 19, 2011·International Journal of Surgery Case Reports·Mohammed A Al-MuharraqiAbdulla Darwish
Sep 5, 2012·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Anshul Aggarwal, Vaishali Keluskar
Jan 10, 2013·The Journal of Laryngology and Otology·R P S PuniaA Dalal
Sep 13, 2013·Ophthalmic Plastic and Reconstructive Surgery·Margarita Sánchez-OrgazRicardo Romero-Martín
Feb 8, 2014·Lymphatic Research and Biology·Shailendra Kapoor
Apr 10, 2014·Case Reports in Medicine·Rajat NangiaIsha Chauhan
May 2, 2014·The Korean Journal of Thoracic and Cardiovascular Surgery·Sung-Yong HongIl-Yong Han
Jun 10, 2014·Advances in Anatomic Pathology·Annikka Weissferdt, Cesar A Moran
Jun 24, 2014·Case Reports in Otolaryngology·Ewa Osuch-WójcikiewiczKazimierz Niemczyk
Jul 22, 2014·Genes, Chromosomes & Cancer·Cristina R AntonescuChristopher D Fletcher
Aug 2, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Luca OlivottiLuigi Martinelli
Aug 12, 2014·Case Reports in Medicine·Hossein VakiliMostafa Jafari
Oct 7, 2014·Indian Journal of Dermatology·Basanti DeviBinodini Behera
Nov 5, 2014·Korean Journal of Pathology·Jin RohChan-Sik Park

❮ Previous
Next ❯

Citations

Feb 26, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Boštjan LuzarEduardo Calonje
Oct 1, 2016·Jornal Vascular Brasileiro·Jefferson da Rocha TenórioLélia Maria Guedes Queiroz

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
surgical resection

Related Concepts

Related Feeds

Castleman Disease

Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Ophthalmic Plastic and Reconstructive Surgery
Margarita Sánchez-OrgazRicardo Romero-Martín
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
S NakamuraY Ota
The Journal of Cardiovascular Surgery
J SandbankE Sternberg
© 2021 Meta ULC. All rights reserved