PMID: 16501828Feb 28, 2006Paper

Epithelioid hemangioma of bone: a potentially metastasizing tumor?

International Journal of Surgical Pathology
Giuseppe FlorisRaf Sciot

Abstract

The case of a 15-year-old boy with a severe swelling of the 2nd toe in the left foot and a large swelling of the left inguinofemoral region is described. Histologic examination of the foot lesion showed a typical epithelioid hemangioma of bone that extended into the soft tissues, with a secondary location in the groin, suggestive of lymph node involvement. Subsequently, imaging also revealed swelling of iliac and para-aortic lymph nodes, which probably indicates further lymph node spread.. Besides the fact that epithelioid hemangioma of the toe has not been reported yet, our case showed a non-continuous localization, most likely in draining lymph nodes. This finding suggests metastatic disease, an event that is extremely rare for epithelioid hemangioma. As such, epithelioid hemangioma might be comparable to another benign vascular tumor, the retiform hemangioendothelioma, which occasionally metastasizes to the lymph nodes without systemic spread.

References

May 1, 1985·Journal of the American Academy of Dermatology·T G Olsen, E B Helwig
Jan 1, 1969·The British Journal of Dermatology·G C Wells, I W Whimster
Dec 1, 1994·The American Journal of Surgical Pathology·K Ben RomdhaneM Ben Othman
Mar 31, 2000·Skeletal Radiology·D E Wenger, L E Wold
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Citations

Apr 1, 2014·Seminars in Diagnostic Pathology·Jesse L HartJerad M Gardner
Aug 16, 2011·Annales de pathologie·Julien CalderaroPierre Bedossa
Jan 11, 2012·Orthopedics·Christopher J Kleck, Matthew J Seidel
Oct 15, 2008·The American Journal of Surgical Pathology·G Petur NielsenAndrew E Rosenberg
Feb 15, 2019·Advances in Anatomic Pathology·Wonwoo Shon, Steven D Billings
Sep 29, 2011·Clinical Orthopaedics and Related Research·Costantino ErraniCristina R Antonescu
Oct 1, 2012·JBJS Case Connector·Aparna Viswanath, John F Nolan
Feb 6, 2017·Acta orthopaedica et traumatologica turcica·Konstantinos TsikopoulosIlias Bisbinas

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