Epithelioid leiomyosarcoma of the external deep soft tissue.

Archives of Pathology & Laboratory Medicine
T YamamotoMayumi Inaba

Abstract

Epithelioid leiomyosarcoma in the external deep soft tissue is extremely rare. Most epithelioid leiomyosarcomas occur in the uterus. We present a case of epithelioid leiomyosarcoma occurring in the muscle of the thigh of a 78-year-old man. Histologically, the tumor predominantly consisted of round or polygonal cells arranged in sheets with a focal spindle cell component. Immunohistochemical analysis revealed that the tumor cells expressed vimentin, alpha-smooth muscle actin, and alpha-sarcomeric actin. The tumor was negative for desmin, S100 protein, glial fibrillary acidic protein, pan-keratin, epithelial membrane antigen, CAM 5.2, HMB-45, leukocyte common antigen, factor VIII-associated antigen, and CD34. Electron microscopically, some tumor cells contained abundant actin-type filaments in their cytoplasm.

References

Sep 1, 1983·The American Journal of Surgical Pathology·K T Chen, C K Ma
May 21, 1999·Virchows Archiv : an International Journal of Pathology·F Lopez-BareaE Burgos-Lizaldez

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Citations

Apr 10, 2003·Archives of Pathology & Laboratory Medicine·Brian Eyden
May 14, 2005·Gynecologic Oncology·Masafumi ToyoshimaNobuo Yaegashi
Jan 18, 2006·International Journal of Dermatology·Marisol Carillo-CorreaGazpar Rico-González
Mar 4, 2006·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Nicolas EfstathopoulosEfstathios Chronopoulos
May 30, 2021·Advances in Anatomic Pathology·Joon Hyuk Choi, Jae Y Ro
Oct 3, 2008·Diagnostic Cytopathology·Maria Manuel LemosM Evelina Mendonça
Sep 22, 2010·Pathology·QingLing ZhangYanQing Ding
Oct 3, 2014·Journal of the American Podiatric Medical Association·Joseph R Kallini, Amor Khachemoune

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