Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center

Gynecologic Oncology
M R DavisRoss S Berkowitz

Abstract

Epithelioid trophoblastic tumor (ETT) is a rare form of gestational trophoblastic neoplasm which is distinct based on its development from intermediate trophoblast cells and nodular growth pattern. The aim of this study is to describe a case series from a single institution with a review of the literature to better understand the clinical characteristics and outcomes for patients with ETT. A retrospective review was performed using the IRB approved New England Trophoblastic Disease Center (NETDC) database from 1998 to 2014. Eight patients were identified of which seven had complete records. Follow-up data was obtained from the longitudinal medical records. Four (57.1%) patients presented with vaginal bleeding and two (28.6%) patients were asymptomatic at presentation. Three (42.9%) patients had extrauterine disease. All three patients with extrauterine disease who received chemotherapy had stable or progressive disease at follow-up. Only two (29%) patients who presented with non-metastatic disease and underwent hysterectomy were alive with no evidence of disease. The mean interval following antecedent pregnancy was 104months. All patients with an interval >4years demonstrated stable or progressive disease despite intensive chem...Continue Reading

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Citations

Feb 22, 2017·Obstetrics & Gynecology Science·Ji-Hye KimJeong-Won Lee
Jul 18, 2019·Archives of Gynecology and Obstetrics·Taohong ZhangYan Xue
Nov 28, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Stephanie M McGregorRicardo R Lastra
Feb 13, 2018·The Journal of Obstetrics and Gynaecology Research·Fang JiangLi-Na Guo
Apr 19, 2018·Medicine·Wangjun LeiYingwei Bao
Aug 1, 2018·Expert Review of Endocrinology & Metabolism·Agedi N Boto, Pei Hui
May 15, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Janelle Sobecki-RauschJohn R Lurain
May 11, 2017·Revista do Colégio Brasileiro de Cirurgiões·Lana DE Lourdes Aguiar LimaAntônio Braga
Feb 20, 2021·Gynecologic Oncology Reports·Kristin A BlackJeanelle Sabourin
Feb 25, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Antonio BragaRoss S Berkowitz
Jul 6, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Baljeet Kaur
Jul 15, 2021·Gynecologic Oncology Reports·Sarah G BellAimee Rolston
Nov 4, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Barry W Hancock, John Tidy
Nov 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mitchell ClarkGeneviève Bouchard-Fortier

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