Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN)

Toxicologic Pathology
Nathália P SouzaSamuel M Cohen


Chronic progressive nephropathy (CPN) occurs commonly in rats, more frequently and severely in males than females. High-grade CPN is characterized by increased layers of the renal papilla lining, designated as urothelial hyperplasia in the International Harmonization of Nomenclature and Diagnostic Criteria classification. However, urothelium lining the pelvis is not equivalent to the epithelium lining the papilla. To evaluate whether the epithelium lining the renal papilla is actually urothelial in nature and whether CPN-associated multicellularity represents proliferation, kidney tissues from aged rats with CPN, from rats with multicellularity of the renal papilla epithelium of either low-grade or marked severity, and from young rats with normal kidneys were analyzed and compared. Immunohistochemical staining for uroplakins (urothelial specific proteins) was negative in the papilla epithelium in all rats with multicellularity or not, indicating these cells are not urothelial. Mitotic figures were rarely observed in this epithelium, even with multicellularity. Immunohistochemical staining for Ki-67 was negative. Papilla lining cells and true urothelium differed by scanning electron microscopy. Based on these findings, we recomm...Continue Reading


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Jun 1, 2012·Toxicologic Pathology·Kendall S FrazierAxel Bube
Oct 30, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gordon C HardSamuel M Cohen
May 26, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Jun Miyazaki, Hiroyuki Nishiyama

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Oct 13, 2019·The FEBS Journal·Girishkumar Kaitholil Kumaran, Israel Hanukoglu
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Methods Mentioned

light microscopy
scanning electron microscopy

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