Epithelium-mesenchyme compartment interaction and oncosis on chemotherapy-induced hair damage

Laboratory Investigation; a Journal of Technical Methods and Pathology
Silvia SelleriCristiano Rumio

Abstract

It is known that chemotherapy induces alopecia in humans, with important psychological and social implications in spite of its reversibility. Among chemotherapeutic drugs, anthracyclines are widely used, yet cause severe alopecia. One of the causes for the elevated sensibility of hair follicles to anthracyclines, and to drugs in general, is the high proliferation rate of follicular epithelium and the long duration of the growth phase (up to 7 years in humans). To clarify the mechanism of anthracycline toxicity, we used a rat model and focused our attention on the morphological alterations in hair follicles induced by doxorubicin. We observed the progression of hair follicle degeneration in the epithelial and mesenchymal compartments until alopecia arose, by both light and electron microscopy. As a first sign of damage, significant apoptosis was detected in the proximal perifollicular connective tissue sheath and sporadically in the matrix, near the interface between matrix and follicular papilla. We propose the apoptotic remodeling of the mesenchymal compartment as a process that is fundamental to the progression of events leading to alopecia. Regarding the epithelial compartment, it is important to note that oncosis was observ...Continue Reading

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Citations

Jul 30, 2009·Cell and Tissue Research·Masashi ShinKunio Fujiwara
Feb 14, 2006·The Journal of Investigative Dermatology·Silvia SelleriCristiano Rumio
Jun 16, 2012·Archives of Dermatological Research·Francesco D'AgostiniSilvio De Flora
Jan 1, 2008·Life Sciences·Naomi Nakashima-KamimuraShigeo Ohta

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