PMID: 9418189Jan 7, 1998Paper

Epitope analysis of birch pollen allergen in Japanese subjects

Journal of Clinical Immunology
Y AbeM Katagiri

Abstract

Birch pollen is a very common cause of nasal allergy (pollinosis) not only in Scandinavia, Europe, Canada, and the northern part of the United States but also in Hokkaido, Japan. We have previously reported a positive association between the HLA-DR9 phenotype and the development of birch pollen allergy in Japanese subjects. However, there is little information about T cell epitopes of birch pollen which are presented by HLA class II molecules other than HLA-DR9. Therefore, we analyzed the difference in T cell epitope usage in patients who had HLA-DR9 versus those who did not. Seven Japanese patients with birch pollinosis were studied. Some groups of peptides representing T cell epitopes (Betula verrucosa; Bet VI peptides, p7-33, p23-46, p138-160) appeared to be shared by the majority, while another peptide (Bet VI p72-95) was recognized predominantly by patients who expressed HLA-DR9 and/or HLA-DQ3 molecules. Moreover, seven T cell clones and eight T cell lines were generated from two patients who did not have HLA-DR9 or HLA-DQ3. Using some of these T cell clones/lines, we investigated the relationship between HLA class II molecules and antigenic peptides. One of these T cell clones recognized antigenic peptides in the context ...Continue Reading

Citations

Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshihiro NagatoMasatoshi Tateno
Apr 2, 2008·Journal of Clinical Immunology·Yuka NomuraYasuaki Harabuchi
Jul 30, 2002·Tissue Antigens·M SakaguchiS Inouye
Sep 29, 2005·Molecular Nutrition & Food Research·Nina KingGary A Bannon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Related Papers

[Hokkaido igaku zasshi] The Hokkaido journal of medical science
K MizumotoM Katagiri
[Hokkaido igaku zasshi] The Hokkaido journal of medical science
M TaneichiM Katagiri
The Journal of Allergy and Clinical Immunology
M Fernández-RivasM Cuevas
© 2021 Meta ULC. All rights reserved