Epitope specificity and T cell receptor usage in type II collagen induced autoimmune ear disease

Cellular Immunology
T J YooK C Cheng

Abstract

An immune response directed against type II collagen (CII) has been reported in several autoimmune diseases including the animal models of collagen-induced arthritis (CIA) and collagen-induced autoimmune ear disease (CIAED). In this communication, we have found that T cells from type II collagen-immunized DBA/1-lac could transfer auricular chondritis to naive mice. The T cells from type II collagen-immunized H-2r and H-2q mice recognize different epitopes from the CB11 peptide of CII. The CII-specific T cells from H-2q background mice recognize peptide residues p121-147 (P1) but do not respond to residues p211-247 (P2). The T cells of H-2r mice immunized with CII respond better to P2 rather than P1. By altering certain amino acids within these epitopes, the response of CII-specific TCR to antigen has been increased or abolished. Our results suggest that the lysine residues at positions 129, 141, and 147 in P1, the arginine residue at position 227, and glutamic acid at position 230 in P2 might play an important role in the trimolecular interaction. Ten clonally distinct T cell hybridomas specific for CII have been established from H-2r B10.RIII mice and the beta chains of their TCR have been analyzed. Three subfamilies, V beta 1...Continue Reading

Citations

Jun 9, 1998·Annals of the New York Academy of Sciences·T J YooH Matsuoka
Dec 18, 2003·The Journal of Clinical Investigation·Veena TanejaChella S David
Sep 21, 2013·Autoimmunity Reviews·Laurent ArnaudZahir Amoura
May 4, 2017·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Bin ZhouPeijie Chen
Jul 20, 2002·The Annals of Otology, Rhinology, and Laryngology·Hiroshi MatsuokaT J Yoo
May 25, 2001·The Annals of Otology, Rhinology, and Laryngology·T J YooX Du
Sep 5, 2002·Acta Oto-laryngologica. Supplementum·T J YooS S Kwon
Dec 1, 1996·Journal of Biomedical Materials Research·M Maruyama, M Ito
Aug 12, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tsunehiko IkedaHidehiro Oku

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