Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: Influence of relapses and immunomodulatory treatments

Journal of Neuroimmunology
Michael KhalilT Berger

Abstract

Only few reports are available on the epitope specificity of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in multiple sclerosis (MS). In the present study we provide a precise characterization of the epitope specificity of serum antibodies directed against the extracellular domain of MOG, including IgG, IgM and IgA immunoglobulin isotypes in 28 relapsing remitting MS patients and report that linear epitopes amino-acid (aa) 37-48 and aa42-53 are immunodominant. Recently experienced relapses intensified the anti-MOG peptide antibody response. Immunomodulatory treatment with interferon-beta or glatiramer-acetate had no major impact on the anti-MOG peptide immunoreactivity after 1 year of therapy.

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Citations

May 10, 2007·Current Neurology and Neuroscience Reports·Eric C Klawiter, Anne H Cross
Dec 29, 2015·Autoimmunity Reviews·Sudarshini RamanathanFabienne Brilot
Aug 29, 2006·Journal of Neuroimmunology·Markus ReindlThomas Berger
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Sep 10, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Patrick PeschlAndreas Lutterotti
Nov 28, 2007·Archives of Pharmacal Research·Kyungwon MinBong-Hee Kim
Sep 10, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie C MayerEdgar Meinl
Dec 17, 2020·Nature Reviews. Drug Discovery·Dennis S W LeeJennifer L Gommerman
Apr 4, 2021·International Journal of Molecular Sciences·Joseph-Patrick W E ClarkeMichael C Levin

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