PMID: 9636203Jun 24, 1998Paper

Epitopes close to the apolipoprotein B low density lipoprotein receptor-binding site are modified by advanced glycation end products

Proceedings of the National Academy of Sciences of the United States of America
X WangR Milne

Abstract

Advanced glycation end products (AGEs) are thought to contribute to the abnormal lipoprotein profiles and increased risk of cardiovascular disease of patients with diabetes and renal failure, in part by preventing apolipoprotein B (apoB)-mediated cellular uptake of low density lipoproteins (LDL) by LDL receptors (LDLr). It has been proposed that AGE modification at one site in apoB, almost 1,800 residues from the putative apoB LDLr-binding domain, may be sufficient to induce an apoB conformational change that prevents binding to the LDLr. To further explore this hypothesis, we used 29 anti-human apoB mAbs to identify other potential sites on apoB that may be modified by in vitro advanced glycation of LDL. Glycation of LDL caused a time-dependent decrease in its ability to bind to the LDLr and in the immunoreactivity of six distinct apoB epitopes, including two that flank the apoB LDLr-binding domain. ApoB appears to be modified at multiple sites by these criteria, as the loss of glycation-sensitive epitopes was detected on both native glycated LDL and denatured, delipidated glycated apoB. Moreover, residues directly within the putative apoB LDLr-binding site are not apparently modified in glycated LDL. We propose that the inabi...Continue Reading

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Citations

Feb 28, 2001·Diabetes, Obesity & Metabolism·D J Betteridge
Apr 3, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·José Luis Sánchez-Quesada, Antonio Pérez
Aug 17, 1999·Annual Review of Nutrition·I Tabas
Jan 18, 2005·Journal of Lipid Research·Chuan-Ming LiChristine A Curcio
Aug 5, 2005·Angiology·Arvindan Veiraiah
Aug 1, 2006·Pathophysiology of Haemostasis and Thrombosis·Elisabeth KollerFranz Koller
Jul 9, 2008·Current Opinion in Lipidology·Nahla YounisPaul N Durrington
Jul 8, 2011·Current Opinion in Lipidology·Handrean Soran, Paul N Durrington
Sep 12, 2020·Metabolism: Clinical and Experimental·Bettina HieronimusKimber L Stanhope

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