Epitopes of HERV-Wenv induce antigen-specific humoral immunity in multiple sclerosis patients

Journal of Neuroimmunology
Giuseppe MameliL A Sechi

Abstract

To verify the serological response mounted against antigenic peptides from HERV-Wenv protein, we analyzed 80 multiple sclerosis (MS) serum samples, 27 of which were re-analyzed after a 6-month follow-up IFN-β therapy, and 73 healthy controls. Indirect ELISAs were carried out to detect antibodies specific for all the synthetic peptides derived from HERV-Wenv. Two antigenic peptides, HERV-Wenv93-108 (31.25%, p<0.0001) and HERV-Wenv248-262 (15%, p=0.02), were highly recognized by MS patients' antibodies when compared to healthy subjects. Moreover, antibody titer against these two peptides slightly decreased after six months of IFN-β-based therapy.

References

Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre RollandPatrice N Marche
Feb 27, 2008·Journal of Neurovirology·Giuseppe MameliAntonina Dolei
Aug 6, 2010·Multiple Sclerosis : Clinical and Laboratory Research·S SotgiuA Dolei
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jul 24, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Giannina ArruGiuseppe Mameli
Oct 9, 2013·Journal of Neuroimmunology·Giuseppe MameliLeonardo A Sechi

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Citations

Jan 29, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tove Christensen
Jul 5, 2016·Seminars in Cell & Developmental Biology·Rosina Giordano-SantiniMassimo A Hilliard
Oct 27, 2017·Acta Neurologica Scandinavica·T Christensen
Dec 6, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Giannina ArruGian Pietro Sechi
Apr 1, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G ArruL A Sechi
Jan 29, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Malgorzata TrelaPaul B Rylance
Mar 30, 2018·Frontiers in Microbiology·Nicole Grandi, Enzo Tramontano
Jan 21, 2021·Pharmaceuticals·Victoria GrögerHolger Cynis
Mar 9, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Maiken Kruse Kristensen, Tove Christensen

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