Epitopes within the HLA-B5,B35 cross-reacting group.

Human Immunology
F E WardD D Kostyu

Abstract

The HLA-B5,B35 cross-reacting group is a large and serologically complex antigen family which includes the World Health Organization-recognized specificities HLA-B5,B51,Bw52,B35,Bw53,B18,Bw70,Bw71, and Bw72. In addition, several variants of antigens in this cross-reacting group have been described in the past but have not yet gained official recognition. A genetic basis for the complexity and the protein and molecular bases of this highly cross-reactive and polymorphic cross-reacting group have yet to be established. The potential contributions of shared amino acid sequences, the occurrence of multiple epitopes on a single HLA-B molecule, and the presence of new HLA-C antigens have been difficult to resolve. To address this issue, we have carefully examined the serologic reactions of more than 900 allo- and monoclonal antibodies (Tenth International Workshop, Third Asia-Oceanic Workshop, and local reagents) versus lymphocytes from 92 individuals of diverse ethnic origin (North American Caucasians, North American blacks, Amerindians, Middle Eastern Caucasians), 84 of whom were informative for the HLA-B5,B35 cross-reacting group and related antigens. Our results demonstrate that the HLA-B5,B35 gene products share different combin...Continue Reading

References

Jun 1, 1975·Tissue Antigens·D D KostyuS Hinostroza
Mar 1, 1978·Tissue Antigens·R PayneP Richiardi
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P ParhamP D Ennis
Mar 1, 1980·Clinical Allergy·M J MorrisD J Lane
Jan 1, 1980·Immunogenetics·D D KostyuD B Amos
Sep 1, 1984·Immunology Today·J Bodmer, W Bodmer

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