EPLIN: a fundamental actin regulator in cancer metastasis?

Cancer Metastasis Reviews
Ross J CollinsAndrew J Sanders

Abstract

Treatment of malignant disease is of paramount importance in modern medicine. In 2012, it was estimated that 162,000 people died from cancer in the UK which illustrates a fundamental problem. Traditional treatments for cancer have various drawbacks, and this creates a considerable need for specific, molecular targets to overcome cancer spread. Epithelial protein lost in neoplasm (EPLIN) is an actin-associated molecule which has been implicated in the development and progression of various cancers including breast, prostate, oesophageal and lung where EPLIN expression is frequently lost as the cancer progresses. EPLIN is important in the regulation of actin dynamics and has multiple associations at epithelial cells junctions. Thus, EPLIN loss in cancer may have significant effects on cancer cell migration and invasion, increasing metastatic potential. Overexpression of EPLIN has proved to be an effective tool for manipulating cancerous traits such as reducing cell growth and cell motility and rendering cells less invasive illustrating the therapeutic potential of EPLIN. Here, we review the current state of knowledge of EPLIN, highlighting EPLIN involvement in regulating cytoskeletal dynamics, signalling pathways and implications...Continue Reading

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Citations

Aug 12, 2018·International Journal of Cancer. Journal International Du Cancer·Ross J CollinsAndrew J Sanders
Sep 22, 2018·Current Opinion in Lipidology·Maaike Kockx, Leonard Kritharides
Mar 3, 2020·Cancer Biomarkers : Section a of Disease Markers·Junjie KongWentao Wang
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Methods Mentioned

BETA
xenograft
co-immunoprecipitation
pull-down
immunoprecipitation
GTPases
nuclear translocation
transfection

Software Mentioned

NetPhos
EPLIN
ClustalW
BioEdit Sequence Alignment

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