Epoetin alfa improves quality of life in patients with cancer: results of metaanalysis

Cancer
Michael JonesLesley Fallowfield

Abstract

Anemia in patients with cancer causes fatigue, weakness, and impaired concentration, negatively impacting quality of life (QOL). In clinical trials involving patients with cancer who had varied characteristics, it has been shown that epoetin alfa treatment increased hemoglobin levels and improved QOL. A systematic review and metaanalysis of data from those trials was conducted to summarize existing knowledge on the role of epoetin alfa in improving QOL for anemic patients with cancer. The Cochrane Library and other data bases were searched for published and unpublished, randomized/controlled and single-arm studies that included > or = 20 patients with cancer per arm, epoetin alfa treatment, and QOL assessment by Cancer Linear Assessment Score (CLAS), Functional Assessment of Cancer Therapy (FACT) scale, Eastern Cooperative Oncology Group (ECOG) scale, and/or Medical Outcomes Study Short-Form 36 (SF-36) scale. Among 11,459 patients from 23 trials, epoetin alfa and control cohorts were indistinguishable (with regard to demographic, clinical, QOL variables) at baseline. Epoetin alfa improved CLAS (20-25%), FACT-Fatigue (17%), and FACT-Anemia (12%) scores (P = 0.05). ECOG scores worsened for control cohorts (P = 0.05); epoetin alfa...Continue Reading

Citations

Oct 9, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C A Rodríguez Sánchez
Nov 3, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A Pelegrí
Aug 1, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Jaime Sanz Ortiz
Oct 17, 2006·Journal of Palliative Medicine·Heike Reineke-BrackeFrank Elsner
Aug 13, 2008·Journal of the National Cancer Institute·Ollie MintonPatrick Stone
Dec 15, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Wendy P J den ElzenJacobijn Gussekloo
Mar 19, 2014·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Tore Kr SchjolbergTone Rustoen
Apr 14, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Giacomo CartenìUNKNOWN OBI/EPO-ITA-01/1 study group
Jul 17, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P J FonsecaA J Lacave
Dec 6, 2012·Journal of Women's Health·Arnold J FriedmanDavid van Wyck
Sep 30, 2008·Wiener klinische Wochenschrift·UNKNOWN Osterreichische Konsensus-Gruppe zum Einsatz von Erythropoese-stimulierenden Proteinen bei Chemotherapie-induzierter Anämie,Christoph Zielinski
Mar 21, 2007·American Journal of Physical Medicine & Rehabilitation·William J Evans, Charles P Lambert
Feb 11, 2016·Seminars in Dialysis·Shan Shan ChenMark Williams
Mar 15, 2011·Experimental Cell Research·Matthew McKinney, Murat O Arcasoy
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Sandra A Mitchell
Dec 19, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·E Le FurO Pradier
Jul 18, 2008·Supportive Cancer Therapy·David H Henry
Jul 16, 2008·Leukemia Research·Domenico Ribatti
Apr 3, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Patrick C Stone, O Minton
Aug 25, 2007·International Journal of Radiation Oncology, Biology, Physics·Mitchell MachtayUNKNOWN Radiation Therapy Oncology Group
Dec 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C BokemeyerUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Taskforce for the Elderly
Oct 6, 2005·Transfusion Medicine·J P WallisN Brewster
Jun 13, 2006·Transfusion Medicine·J Laird
Mar 18, 2016·CNS Oncology·Arash AsherJennifer K Hughes
Oct 6, 2005·American Journal of Obstetrics and Gynecology·Vivian E von GruenigenMichael P Hopkins
May 15, 2015·Obstetrical & Gynecological Survey·Arnold J FriedmanLawrence Tim Goodnough
Jan 25, 2008·Palliative Medicine·Lukas RadbruchUNKNOWN Research Steering Committee of the European Association for Palliative Care (EAPC)
Mar 14, 2008·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Stacy S ShordSandra Cuellar
Mar 2, 2006·The Annals of Pharmacotherapy·Aaron D KillianAlisa E Goetz
Jul 9, 2010·The Cochrane Database of Systematic Reviews·Ollie MintonPatrick Stone
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Thomy ToniaJulia Bohlius
Jun 3, 2005·The American Journal of Gastroenterology·R Todd StravitzMitchell L Shiffman
Mar 30, 2006·British Journal of Cancer·P M WilkinsonUNKNOWN EPO-INT-45 Study Group
Sep 26, 2009·The Oncologist·Jerry L SpivakHeinz Ludwig
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Karen M Devon, Robin S McLeod

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