Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Kristina T KudelkoVinicio De Jesus Perez

Abstract

We describe a case of severe drug-induced interstitial pneumonitis in a woman with idiopathic pulmonary arterial hypertension receiving epoprostenol confirmed by a drug T-cell proliferation assay. Proliferation assays were completed in our patient and in a healthy control. Isolated T cells were incubated with CD3-depleted peripheral blood mononuclear cells and then stimulated to proliferate with (3)H-thymidine in the presence of epoprostenol, other prostanoid analogs, and controls. A significant (p < 0.001) T-cell proliferation response occurred in our patient in the presence of epoprostenol alone. There was a trend towards an increased T-cell response to treprostinil but this was statistically insignificant. There was no significant T-cell response to the diluent alone, normal saline, iloprost, or alprostadil. There was no significant proliferation to any drug in the healthy control. Hence, a drug T-cell proliferation assay confirmed that epoprostenol can rarely incite a profound inflammatory response in the pulmonary interstitium.

References

Feb 1, 1996·The New England Journal of Medicine·R J BarstUNKNOWN Primary Pulmonary Hypertension Study Group
Feb 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B Nyfeler, W J Pichler
Mar 23, 2002·The American Journal of Cardiology·Suleiman KharabshehMark Kozak
Jul 13, 2002·Chest·Gregory S AhearnVictor F Tapson
Apr 6, 2004·Clinics in Chest Medicine·Ulrich CostabelJosune Guzman
Apr 6, 2004·Clinics in Chest Medicine·Douglas B Flieder, William D Travis
Aug 19, 2004·Respiration; International Review of Thoracic Diseases·Philippe CamusPascal Foucher
May 8, 2008·British Journal of Clinical Pharmacology·Desak Ketut ErnawatiJeffery David Hughes

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Citations

Aug 3, 2012·The American Journal of Cardiology·Vinicio A de Jesus PerezRoham T Zamanian

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