PMID: 7179301Sep 1, 1982

Epoxide hydrolase activity in small biopsy samples of preneoplastic and neoplastic rat liver

Toxicology Letters
U A BoelsterliG Zbinden

Abstract

Epoxide hydrolase (EH) activity was measured in serial fine-needle aspiration biopsy (FNAB) samples of male rats chronically treated with the hepatocarcinogen, N-nitrosomorpholine (NNM, 10 mg/100 ml drinking water). The development of neoplasia was confirmed histopathologically at the end of the experiment. The enzyme activity was significantly increased after 2 days of NNM administration and reached a 3 to 4-fold increase after 2 weeks that remained stable throughout the experiment. Although EH is not related to the metabolism of NNM, the induction of enzyme as readily recognized with the FNAB method might be a useful marker in the attempt to characterize hepatocarcinogenic substances in rats.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W LevinM J Griffin
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A B NovikoffP E Thomas
Dec 14, 1979·Biochemical and Biophysical Research Communications·P BentleyW Stäubli
Feb 1, 1980·AJR. American Journal of Roentgenology·J ZornozaJ Lukeman
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·A Y Lu, G T Miwa

Citations

Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T K CollierU Varanasi

Related Concepts

9,10-Epoxypalmitic Acid Hydrase
Malignant Neoplasm of Liver
Condition, Preneoplastic

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