Epoxy Coenzyme A Thioester pathways for degradation of aromatic compounds.

Applied and Environmental Microbiology
Wael Ismail, Johannes Gescher

Abstract

Aromatic compounds (biogenic and anthropogenic) are abundant in the biosphere. Some of them are well-known environmental pollutants. Although the aromatic nucleus is relatively recalcitrant, microorganisms have developed various catabolic routes that enable complete biodegradation of aromatic compounds. The adopted degradation pathways depend on the availability of oxygen. Under oxic conditions, microorganisms utilize oxygen as a cosubstrate to activate and cleave the aromatic ring. In contrast, under anoxic conditions, the aromatic compounds are transformed to coenzyme A (CoA) thioesters followed by energy-consuming reduction of the ring. Eventually, the dearomatized ring is opened via a hydrolytic mechanism. Recently, novel catabolic pathways for the aerobic degradation of aromatic compounds were elucidated that differ significantly from the established catabolic routes. The new pathways were investigated in detail for the aerobic bacterial degradation of benzoate and phenylacetate. In both cases, the pathway is initiated by transforming the substrate to a CoA thioester and all the intermediates are bound by CoA. The subsequent reactions involve epoxidation of the aromatic ring followed by hydrolytic ring cleavage. Here we di...Continue Reading

References

Sep 1, 1976·Journal of General Microbiology·J A Buswell, J S Clark
Oct 1, 1992·Biological Chemistry Hoppe-Seyler·F LöfflerF Lingens
Jan 1, 1992·Annual Review of Microbiology·S HarayamaE L Neidle
Dec 1, 1992·Applied and Environmental Microbiology·A SchmitzR Eichenlaub
Jun 1, 1992·Applied and Environmental Microbiology·E GrundR Eichenlaub
Jan 1, 1988·Annual Review of Microbiology·W C Evans, G Fuchs
Dec 1, 1984·The Journal of Applied Bacteriology·R Sleat, J P Robinson
Jan 1, 1996·Annual Review of Microbiology·C S Harwood, R E Parales
Jan 1, 1997·Advances in Microbial Physiology·C S Butler, J R Mason
Jan 1, 1997·Journal of Bacteriology·C S Harwood, J Gibson
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·P G EglandC S Harwood
Sep 5, 1997·Science·F R BlattnerY Shao
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·E R OliveraJ M Luengo
Sep 25, 1998·The Journal of Biological Chemistry·A FerrándezE Díaz
Nov 5, 1999·Applied and Environmental Microbiology·J OverhageA Steinbüchel
Feb 24, 2001·Journal of Basic Microbiology·R P RezendeV R Linardi
Apr 27, 2002·Applied and Environmental Microbiology·Bjarke B ChristensenSøren Molin
Jun 29, 2002·The Journal of Biological Chemistry·Yasuhiro Takahashi, Umechiyo Tokumoto
Aug 13, 2002·Molecular Genetics and Genomics : MGG·R RostG Burchhardt
Aug 22, 2002·Archives of Microbiology·Magdy el-Said MohamedGeorg Fuchs
Oct 26, 2002·Journal of Bacteriology·Johannes GescherGeorg Fuchs
Nov 5, 2002·Current Opinion in Chemical Biology·Matthias BollJohann Heider
Mar 29, 2003·Journal of Molecular Evolution·Eugenio NotomistaAnna Tramontano
Jul 9, 2003·European Journal of Biochemistry·Wael IsmailGeorg Fuchs
Oct 11, 2003·FEMS Microbiology Reviews·Joseph G LeahySuzanne M Morcomb

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Citations

Mar 4, 2014·PloS One·Isabel Natalia Sierra-GarcíaValéria Maia de Oliveira
Dec 1, 2017·Microorganisms·Ouwei Wang, John D Coates
Dec 4, 2019·Biotechnology for Biofuels·Raj MoryaIndu Shekhar Thakur
Jul 18, 2017·MicrobiologyOpen·Maikel Gilberto Fernández-LópezMa Laura Ortiz-Hernández
Jul 18, 2018·Polish Journal of Microbiology·Sarah AldhafiriWael A Ismail
Dec 22, 2019·Extremophiles : Life Under Extreme Conditions·Ahmad Fareez Ahmad RosleeSiti Aqlima Ahmad
Mar 16, 2021·Bioscience, Biotechnology, and Biochemistry·Ryota MoriuchiNaoto Ogawa

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