Epoxygenase Inhibitors Attenuate the Stimulatory Effect of Glutoxim on Na+ Transport in Frog Skin

Doklady. Biochemistry and Biophysics
Z I KrutetskayaA D Nozdrachev

Abstract

Using voltage-clamp technique, the involvement of epoxygenases in immunomodulatory drug glutoxim regulation of Na+ transport in frog skin was investigated. We have shown for the first time that preincubation of the frog skin with epoxygenase inhibitors econazole or proadifen almost completely inhibits the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of the enzymes and/or products of epoxygenase oxidation pathway of arachidonic acid metabolism in glutoxim effect on Na+ transport in frog skin epithelium.

References

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Jan 11, 2013·Current Opinion in Nephrology and Hypertension·Jorge Capdevila, Wenhui Wang
Aug 27, 2013·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·Z I KrutetskayaA D Nozdrachev
Jul 14, 2017·Journal of the American Society of Nephrology : JASN·Fan Fan, Richard J Roman
Jul 21, 2017·Doklady. Biochemistry and Biophysics·Z I KrutetskayaA D Nozdrachev

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