EPSP amplitude modulation at the rat Ia-alpha motoneuron synapse: effects of GABAB receptor agonists and antagonists

Journal of Neurophysiology
K R PeshoriL M Mendell

Abstract

The object of this study was to examine the relationship between excitatory postsynaptic potential (EPSP) amplitude, posttetanic potentiation, and EPSP amplitude modulation at synapses made by group Ia afferents on motoneurons in the rat. These relationships were evaluated in cells in untreated rats and in cells in rats treated with the gamma-aminobutyric acid-B (GABAB) receptor agonist baclofen and antagonist CGP-35348, which were used to manipulate Ca2+ entry into presynaptic terminals and consequently probability of transmitter release from them. There was no evidence for postsynaptic action of these drugs from measurement of their effects on motoneuron properties. During high-frequency stimulation (32 shock bursts at 167 Hz), EPSP amplitude either decreased (negative modulation) or increased (positive modulation) in response to successive stimuli at different connections. In untreated rats this frequency-dependent amplitude modulation behavior was inversely but weakly correlated with EPSP amplitude measured at low frequency. Intravenous (iv) administration of the GABAB agonist, baclofen, produced a marked and progressive decrease in EPSP amplitude measured at low frequency coincident with a change in frequency-dependent EPS...Continue Reading

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Citations

Sep 21, 2000·The European Journal of Neuroscience·S TowersN G Bowery
Oct 19, 2004·Muscle & Nerve·T George HornbyW Zev Rymer
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Oct 5, 2002·Journal of Neurophysiology·M Enríquez-DentonJ B Nielsen
Sep 24, 2004·The Journal of Pharmacology and Experimental Therapeutics·Victor L ArvanianLorne M Mendell
Feb 28, 2001·Journal of Child Neurology·F J ThompsonP Bose
Sep 21, 2010·The European Journal of Neuroscience·Jeffrey C PetruskaLorne M Mendell
Mar 17, 1999·The Journal of Comparative Neurology·M Margeta-MitrovicA I Basbaum
Aug 20, 2021·Physiological Reports·Rodolfo Delgado-LezamaVinicio Granados-Soto

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