Abstract
To determine the prevalence of Epstein-Barr virus (EBV) infection in primary extranodal lymphoma of the head and neck (PELHN) in immunocompetent patients. PELHN represents 16.18% of all lymphoma diagnosed at the National Cancer Institute, Cairo. Although EBV infection is highly associated with lymphoma in immunocompromised patients, the situation in immunocompetent patients is still unclear. The study included 50 PELHN (11 cases in the nose and paranasal sinuses, 11 in the nasopharynx, 13 in the tonsils, seven in the oropharynx and eight in the oral cavity), five reactive lymph nodes, 15 normal nasopharyngeal tissue and 25 throat washes of healthy subjects from Egypt. Cases and controls were assessed for the presence of EBV by polymerase chain reaction (PCR) and in situ hybridization techniques, the presence of 30 base pair deletion of the LMP-1 (del-LMP1) gene and for the expression of p53, Ki67, bcl-2 and Bax by immunohistochemistry. This was also correlated with the clinical outcome of patients. EBV was detected in 90% and 70% of the cases using EBER in situ hybridization and PCR, respectively. All cases of nasal type lymphoma were positive for EBV. del-LMP1 gene was detected in 24/35 of EBV+ cases (68.6%), whereas 11 cases ...Continue Reading
References
Jun 28, 1991·Cell·S HendersonA Rickinson
May 1, 1991·Breast Cancer Research and Treatment·G N Stemmermann
Mar 1, 1991·Journal of Clinical Pathology·N O'Connor
Sep 15, 1995·International Journal of Cancer. Journal International Du Cancer·Y S ChangS T Liu
Oct 1, 1995·Cancer·N AnwarE S Jaffe
Aug 1, 1996·Journal of Virology·Q Y YaoA B Rickinson
Aug 1, 1995·Histopathology·J Van GorpJ G Van Den Tweel
May 30, 1998·Pathology, Research and Practice·M V PreciadoS Grinstein
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·A K ChiangG Srivastava
Mar 17, 1999·International Journal of Cancer. Journal International Du Cancer·L G LabrecqueB E Griffin
Jul 14, 1999·Head & Neck·A CalzolariS Di Lollo
Aug 19, 1999·Journal of the National Cancer Institute·M BonnetI Joab
Dec 22, 1999·Oncogene·K BarnouinX Lu
Dec 28, 1999·Leukemia & Lymphoma·J SuzumiyaM Kikuchi
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G E KimB S Kim
Jan 29, 2000·Molecular and Cellular Biology·M Wade, M J Allday
Mar 4, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S Camilleri-BroëtM Raphaël
Sep 30, 2000·Histopathology·M S ChangY I Kim
Jan 11, 2001·Journal of Virology·T VincentP L Leopold
Mar 7, 2001·Human Pathology·B PetitP Gaulard
Aug 16, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·I T LeongD Mock
Apr 17, 2002·Human Pathology·Charalambos C SolomidesHenry Simpkins
Citations
Jun 15, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sharon EladUNKNOWN Viral Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/Internationa
Apr 25, 2013·PloS One·Yuan MaoJin Zhu
Apr 21, 2012·ISRN Oncology·Marinho MarquesIguaracyra Araújo
Mar 14, 2013·Iranian Red Crescent Medical Journal·Mohammad Javad AshrafBita Valibeigi
Mar 7, 2014·BMC Cancer·Xin HeLiansheng Huang
Sep 6, 2007·Leukemia & Lymphoma·Abdel-Rahman ZekriMohamed Hafez
Mar 6, 2012·Histopathology·Wei-Ren LuoKai-Tai Yao
Aug 30, 2012·Journal of the Egyptian National Cancer Institute·Abdel-Rahman N ZekriZeinab K Hassan
Jul 22, 2017·PLoS Pathogens·Ting-Ting CaiJiang Li
Apr 28, 2006·Blood·Didier DecaudinLivia Lumbroso-Le Rouic
Jun 25, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Jing ZhangZhong-Jun Xia
Mar 5, 2021·Frontiers in Oncology·Solomon O RotimiBodour Salhia