Epstein-Barr viral infection in extranodal lymphoma of the head and neck: correlation with prognosis and response to treatment

Histopathology
A A BahnassyN M Mokhtar

Abstract

To determine the prevalence of Epstein-Barr virus (EBV) infection in primary extranodal lymphoma of the head and neck (PELHN) in immunocompetent patients. PELHN represents 16.18% of all lymphoma diagnosed at the National Cancer Institute, Cairo. Although EBV infection is highly associated with lymphoma in immunocompromised patients, the situation in immunocompetent patients is still unclear. The study included 50 PELHN (11 cases in the nose and paranasal sinuses, 11 in the nasopharynx, 13 in the tonsils, seven in the oropharynx and eight in the oral cavity), five reactive lymph nodes, 15 normal nasopharyngeal tissue and 25 throat washes of healthy subjects from Egypt. Cases and controls were assessed for the presence of EBV by polymerase chain reaction (PCR) and in situ hybridization techniques, the presence of 30 base pair deletion of the LMP-1 (del-LMP1) gene and for the expression of p53, Ki67, bcl-2 and Bax by immunohistochemistry. This was also correlated with the clinical outcome of patients. EBV was detected in 90% and 70% of the cases using EBER in situ hybridization and PCR, respectively. All cases of nasal type lymphoma were positive for EBV. del-LMP1 gene was detected in 24/35 of EBV+ cases (68.6%), whereas 11 cases ...Continue Reading

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Citations

Jun 15, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sharon EladUNKNOWN Viral Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/Internationa
Aug 30, 2012·Journal of the Egyptian National Cancer Institute·Abdel-Rahman N ZekriZeinab K Hassan
Apr 28, 2006·Blood·Didier DecaudinLivia Lumbroso-Le Rouic
Mar 5, 2021·Frontiers in Oncology·Solomon O RotimiBodour Salhia

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