Epstein-Barr viral load assessment in immunocompetent patients with fulminant infectious mononucleosis

Archives of Internal Medicine
Jan A M van LaarJaap Deinum

Abstract

We describe 2 immunocompetent adolescents with fulminant infectious mononucleosis and virus-associated hemophagocytosis. A new quantitative polymerase chain reaction revealed high serum Epstein-Barr virus DNA levels in these patients. One patient died with an increasing viral load not responding to corticosteroids followed by antiviral and intensified immunomodulatory treatment. The other patient received corticosteroids and acyclovir at diagnosis; her rapid recovery was heralded by a steep decline of viral load. We propose monitoring the clinical course of fulminant infectious mononucleosis in immunocompetent patients by Epstein-Barr virus DNA quantification and prompt corticosteroid and antiviral therapy when viral load is high.

Citations

Sep 24, 2010·Virology Journal·Meav-Lang J LayUNKNOWN Ausimmune Investigator Group (AIG)
May 6, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Samira Fafi-KremerPatrice Morand
Mar 12, 2013·Annales de pathologie·Caroline LacosteBéatrix Cochand-Priollet
Jan 1, 2008·The Journal of Molecular Diagnostics : JMD·Samira Fafi-KremerJean-Marie Seigneurin
Oct 26, 2012·Journal of Gastroenterology and Hepatology·Kavitha SubramaniamPaul Pavli
May 11, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Casper RokxBart J A Rijnders
Apr 24, 2018·Journal of Pediatric Hematology/oncology·Elpis MantadakisAggelos Tsalkidis
Mar 9, 2021·Curēus·Bessy S Flores ChangIvette Vigoda

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