Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression

Frontiers in Oncology
Farhan S CyprianAla-Eddin Al Moustafa

Abstract

Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, it is well established that onco-proteins of EBV (LMP1, LMP2A, and EBNA1) and high-risk HPVs (E5 and E6/E7) play an important role in the initiation and/or progression of several human carcinomas, including cervical, oral, and breast. More significantly, it has been recently pointed out that viral onco-proteins of EBV and high-risk HPVs can be co-present and consequently cooperate to initiate and/or amplify epithelial-mesenchymal transition (EMT), which is the hallmark of cancer progression and metastasis. This could occur by β-catenin, JAK/STAT/SRC, PI3k/Akt/mTOR, and/or RAS/MEK/ERK signaling pathways, which onco-proteins of EBV and HPVs share. This review presents the most recent advances related to EBV and high-risk HPVs onco-proteins interactions and their roles in the progression of human carcinomas especially oral and breast via the initiation of EMT.

References

Jan 9, 1999·Oncogene·M Thomas, L Banks
Sep 10, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·C G DeshpandeR Longnecker
Dec 17, 2002·Critical Reviews in Oncology/hematology·Jaap M MiddeldorpChris J L M Meijer
Jul 5, 2003·Cancer Cell·Hashmat A SikderRhoda M Alani
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sylvia FongPierre-Yves Desprez
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew P Thompson, Razelle Kurzrock
Jul 17, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rosemary E ZunaS Terence Dunn
Oct 29, 2004·Nature Reviews. Cancer·Lawrence S Young, Alan B Rickinson
Jan 12, 2005·Breast Cancer Research : BCR·Ethel-Michele de VilliersCharles E Buck
Feb 22, 2005·The Journal of General Virology·Sharon Shnitman MagalLevana Sherman
Mar 9, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·John Doorbar
Jun 18, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Ahmet KalkanMehmet Z Doymaz
Oct 14, 2005·British Journal of Cancer·C-Y KanN J Whitaker
Nov 8, 2006·The Breast : Official Journal of the European Society of Mastology·Katja LindelGuenther Gruber
Apr 4, 2007·International Journal of Cancer. Journal International Du Cancer·Jennifer S SmithGary M Clifford
Aug 28, 2007·Cell Cycle·Amber YasmeenAla-Eddin Al Moustafa
Jan 19, 2008·Biochimica Et Biophysica Acta·Margaret E McLaughlin-Drubin, Karl Munger
Feb 9, 2008·Clinical Biochemistry·Shereen FawzyNahla Mohammad Awad
Sep 11, 2008·Current Pharmaceutical Design·Ala-Eddin Al MoustafaAmber Yasmeen
Nov 11, 2008·Seminars in Cancer Biology·Christian Münz, Ann Moormann
Nov 15, 2008·Journal of Cancer Research and Clinical Oncology·Marla Karine Amarante, Maria Angelica Ehara Watanabe
Sep 3, 2009·British Journal of Cancer·B HengJ S Lawson
Oct 20, 2009·Virus Genes·Raffaella GhittoniMassimo Tommasino
Jun 16, 2010·The Breast : Official Journal of the European Society of Mastology·Mohamed HachanaMounir Trimeche
Jan 6, 2011·Pathology Oncology Research : POR·Maryam KadivarNiloufar Hosseini
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg

❮ Previous
Next ❯

Citations

Apr 9, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul W Ewald, Holly A Swain Ewald
Nov 18, 2018·The Journal of Clinical Endocrinology and Metabolism·Terry J Smith
Mar 19, 2020·Human Vaccines & Immunotherapeutics·Mohammed I MalkiHamda A Al-Thawadi
Jul 22, 2020·Critical Reviews in Microbiology·Diletta Francesca SquarzantiBarbara Azzimonti
Jul 24, 2018·Frontiers in Oncology·Hamda Al-ThawadiAla-Eddin Al Moustafa
Jan 22, 2021·Critical Reviews in Microbiology·Paola ZanettaBarbara Azzimonti
Jun 11, 2021·Infectious Agents and Cancer·James S Lawson, Wendy K Glenn
Aug 18, 2021·BMC Cancer·Javid Sadri NahandFarah Bokharaei-Salim
Oct 9, 2021·Human Vaccines & Immunotherapeutics·Ishita GuptaHalema F Al-Farsi

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Xue ChenYa Cao
Advances in Experimental Medicine and Biology
Zhi LiLun-Quan Sun
Journal of the National Cancer Institute
M BonnetI Joab
© 2022 Meta ULC. All rights reserved