Epstein-Barr virus and rheumatoid arthritis: cellular and molecular aspects.

Rheumatology International
M Lotz, J Roudier

Abstract

Several lines of research have indicated a possible association of the Epstein-Barr virus and rheumatoid arthritis (RA). The earliest evidence suggested that RA patients develop a stronger humoral immune response to EBV nuclear antigens (EBNA) which may in part account for the increased titers of antibody to the RA nuclear antigen (RANA). It was then pointed out that mononuclear cells from RA patients may be impaired in their capacity to control EBV infection. This may be related to a decrease in the production of IFN gamma and a consequence of monocyte-derived inhibitory activities. These cellular defects, however, are not specific for RA and may rather be the result of chronic inflammatory responses. These findings and the lack of increased virus presence in RA tissues did not provide a strong basis for a possible association of EBV and RA. A new concept for this association is now being tested on the basis of the sequence homology between the genetic RA susceptibility determinant HLA DR4 and the EBV glycoprotein 110.

References

Apr 20, 1978·The New England Journal of Medicine·P Stastny
Aug 1, 1977·The Journal of Experimental Medicine·D A Thorley-LawsonJ L Strominger
Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·W HenleH C Kwan
Aug 1, 1988·European Journal of Immunology·C D Tsoukas, J D Lambris
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P K GregersenJ Schwenzer
Jan 1, 1987·Journal of Clinical Immunology·G T NepomB S Nepom
Sep 15, 1971·International Journal of Cancer. Journal International Du Cancer·G HenleG Klein
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G Miller, M Lipman
Dec 20, 1973·The New England Journal of Medicine·R S ChangC F Abildgaard
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J D FingerothD T Fearon
Dec 1, 1984·Arthritis and Rheumatism·P B BillingsJ H Vaughan
Sep 18, 1982·Lancet·J L ZieglerK Yamamoto
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T DambaughE Kieff
Sep 1, 1981·The Journal of Experimental Medicine·A G BirdK Nilsson
Nov 19, 1981·The New England Journal of Medicine·G TosatoR M Blaese
Jan 1, 1983·European Journal of Immunology·U AnderssonG Bird
Oct 1, 1983·The Australian Journal of Experimental Biology and Medical Science·D J MossR G Kane
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E A GroganG Miller
Nov 14, 1981·British Medical Journal·J C WoodrowG Zaphiropoulos

❮ Previous
Next ❯

Citations

Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H InoueI Saito
Aug 16, 2000·Arthritis and Rheumatism·W K IpC S Lau
Oct 21, 2011·Autoimmunity·Barbara L GoldsteinKaren H Costenbader
Nov 22, 2013·The American Journal of Dermatopathology·Angel Fernandez-Flores
Jul 13, 2001·Infectious Disease Clinics of North America·E BouzaP Muñoz
Jul 13, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Eric Toussirot, Jean Roudier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.