Epstein-Barr virus and rheumatoid arthritis

Joint, Bone, Spine : Revue Du Rhumatisme
Nathalie Balandraud, Jean Roudier

Abstract

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, with a 0.5% worldwide prevalence. The cause of RA remains unknown, however both genetic and environmental factors may contribute to its development. Among these is the Epstein-Barr virus (EBV). Here, we discuss several aspects of the close relationship between EBV and RA. Patients with RA have impaired control of EBV infection. Indeed, they have high titres of antibodies against EBV antigens. Their peripheral blood T lymphocytes are less efficient at controlling the outgrowth of EBV-infected B cells. RA patients have more EBV-infected B cells than normal controls, leading to a 10-fold systemic EBV overload. Post-transplant lymphoproliferative disorder (PTLPD) is a polyclonal EBV-positive B lymphocyte proliferation, which can evolve into an EBV-positive B cell lymphoma. RA patients also have an increased risk of developing EBV-associated lymphoproliferative disorder (LPD). Hence the need to monitor EBV load when treating RA patients with immunosuppressors. EBV, a widespread virus, highly recognized by antibodies but never eliminated, is an ideal candidate to trigger chronic immune complex disease. Anti-EBV antibody responses should be considered as one of t...Continue Reading

Citations

Dec 24, 2019·Journal of Clinical and Experimental Hematopathology : JCEH·Shuntaro Saito, Tsutomu Takeuchi
Apr 19, 2018·Frontiers in Microbiology·Andrzej GórskiJan Borysowski
Feb 9, 2019·Clinical Rheumatology·Naim MahroumHoward Amital
Jul 28, 2020·Clinical and Experimental Medicine·Zyanya Reyes-CastilloJ Francisco Muñoz-Valle
Jul 2, 2019·Journal of Clinical and Experimental Hematopathology : JCEH·Michihide TokuhiraMasahiro Kizaki
Jul 11, 2020·Cell·Xing LiuJuan I Fuxman Bass
Jan 26, 2021·Frontiers in Immunology·Gunnar Houen, Nicole Hartwig Trier
Feb 12, 2021·Viruses·Francesca GugliesiMatteo Biolatti
Feb 19, 2021·Frontiers in Cellular and Infection Microbiology·Mila Collados Rodríguez
Dec 10, 2019·Joint, Bone, Spine : Revue Du Rhumatisme·Marie-Christophe BoissierNatacha Bessis
Jul 10, 2021·Frontiers in Microbiology·Vincent Jean-PierreRaphaële Germi

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