Epstein-Barr virus-associated diffuse large B-cell lymphoma: diagnosis, difficulties and therapeutic options

Expert Review of Anticancer Therapy
Ana Battle-LopezM A Piris

Abstract

Epstein Barr Virus (EBV)-positive diffuse large B cell lymphoma (DLBCL) most frequently affects elderly patients, without previous immunosuppression, with frequent extra-nodal involvement and whose disease runs an aggressive clinical course with high International Prognostic Index (IPI) scores. Various EBV-related transforming mechanisms, much favored by immunosenescence, have been described, including activation of the NFKB transcriptional program. Elderly patients show poor survival after treatment with conventional CHOP regimens, even after addition of Rituximab. Younger patients, however, have a better outcome with a similar prognosis to EBV-negative DLBCL cases. New therapeutic strategies, including treatments targeting EBV, new drugs directed against specific pathways constitutively activated in these lymphomas, and new specific conjugate antibodies against molecules usually expressed in the tumor cells, such as CD30, are described.

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Citations

Oct 1, 2019·The American Journal of Surgical Pathology·Mina L XuAlejandro A Gru
May 3, 2019·The Journal of Craniofacial Surgery·Sara Ferreira Dos Santos CostaOslei Paes de Almeida
Feb 22, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Carla Isabelly Rodrigues-FernandesFelipe Paiva Fonseca

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