Epstein-Barr virus-associated gastric adenocarcinomas among Koreans

American Journal of Clinical Pathology
W S ShinK W Min

Abstract

Epstein-Barr virus (EBV)-associated gastric carcinomas have been reported from various regions of the world. Epstein-Barr virus appears to be pathogenetically related to some gastric carcinomas. To determine the incidence of EBV association with gastric carcinomas among Koreans, the authors have studied EBV genome expression in 89 consecutive patients with gastric carcinomas diagnosed at the Catholic University Hospitals in Seoul, Korea, using in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs), and immunohistochemistry for EBV latent membrane proteins (LMP) and CD21 antigen on paraffin sections. Thirty-seven gastric specimens with benign ulcer disease were used controls. EBV-encoded small RNAs were expressed in tumor cell nuclei in 12 patients (13.5%). None of the controls or benign portions of the cases were positive. In the positive cases, all tumor cell nuclei were uniformly stained and the staining intensity was strong. Immunohistochemistry for LMP was positive in 3 of 12 EBERs positive patients and none of EBERs negative patients. EBV latent membrane proteins was localized only in the lymphoid cells infiltrating the tumor in two patients, and tumor cells as well as infiltrating lymphoid cells in one patient. Th...Continue Reading

Citations

Dec 17, 1997·International Journal of Cancer. Journal International Du Cancer·S A GaletskyM Tokunaga
May 26, 1998·Japanese Journal of Cancer Research : Gann·M TajimaK Okinaga
Apr 13, 2000·International Journal of Experimental Pathology·S B GarciaN A Wright
Oct 17, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·T KudoS Ichiyama
Apr 16, 2005·Journal of Korean Medical Science·Jin-Seok LeeHyeon-Jin Park
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M ParkJ-H Kang
Jul 15, 1999·Journal of Clinical Gastroenterology·H YanaiK Takada
Aug 12, 2003·Oncogene·Lawrence S Young, Paul G Murray
Oct 1, 2005·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Mee Soo Chang, Woo Ho Kim
May 23, 2015·Medicine·Xin-Zu ChenHermann Brenner
Jul 15, 1999·Journal of Clinical Gastroenterology·M Rugge, R M Genta
Nov 2, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L F LopesC E Bacchi
Apr 2, 2009·Journal of Gastroenterology and Hepatology·Ju-Han LeeYoung-Sik Kim
Apr 9, 2016·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jong-Myon Bae, Eun Hee Kim
Dec 11, 1999·Carcinogenesis·C T Stadtländer, J W Waterbor
Aug 26, 1998·Journal of Gastroenterology and Hepatology·J NishikawaK Okita
Apr 13, 2006·Virchows Archiv : an International Journal of Pathology·Tetsuya UeoShigeo Yokoyama
Dec 25, 2008·Expert Review of Anticancer Therapy·Philip Abraham Kovoor, Jimmy Hwang
Feb 11, 2016·The Open Virology Journal·Abdelwahid Saeed AliIan M Jones
Apr 27, 2000·Critical Reviews in Oncology/hematology·J L Hsu, S L Glaser

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