Epstein-Barr virus-associated Hodgkin's disease following renal transplantation.

The Korean Journal of Internal Medicine
Jung-Hye ChoiIn-Soon Kim

Abstract

Post-transplant lymphoproliferative disorders (PTLD) have been recognized as a complication of immunosuppression and occur with a reported incidence of 1 to 8% of recipients receiving solid organ transplantation. PTLD are classified into two major categories, polymorphic and monomorphic PTLD. The majority of the monomorphic PTLD cases are non-Hodgkin's lymphoma of B-cell origin. Hodgkin's disease is not part of the typical spectrum of PTLD; however, it has been rarely reported. We describe a case of Hodgkin's disease following renal transplantation. A 41-year-old man developed right cervical lymphadenopathy following renal transplantation 116 months previously for chronic renal failure of unknown origin. He had been taking cyclosporine, mycophenolate mofetil and prednisone. A lymph node biopsy revealed mixed cellularity Hodgkin's disease. Immunohistochemical staining was positive for CD30 and EBV-latent membrane protein-1. No other site of disease was identified. The immunosuppressive agents were reduced (mycophenolate mofetil was discontinued, cyclosporine dose reduced from 200 mg to 150 mg and prednisone continued at 5 mg). After 2 cycles of ABVD followed by radiation therapy (3600 cGy), he achieved complete remission.

References

Jan 15, 1996·Transplantation·J L GarnierJ L Touraine
Mar 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P J BiermanT C Greiner
Nov 1, 1996·Journal of Pediatric Hematology/oncology·R K GoyalD B Wilson
Apr 27, 2000·Advances in Renal Replacement Therapy·I Penn
Nov 28, 2002·Pediatric Transplantation·R D Holmes, R J Sokol
Mar 5, 2003·The Lancet Infectious Diseases·Karen F Macsween, Dorothy H Crawford
Feb 27, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rokshana Shroff, Lesley Rees
Mar 11, 2004·Pediatric Transplantation·Vikas R DharnidharkaRobert S Fennell

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Citations

Apr 15, 2009·International Journal of Cancer. Journal International Du Cancer·Lesley A AndersonEric A Engels

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Methods Mentioned

BETA
biopsy

Software Mentioned

CytaBOM

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