PMID: 9658436Jul 11, 1998Paper

Epstein-Barr virus-associated lymphoproliferative disorder after unrelated bone marrow transplantation in a young child with Wiskott-Aldrich syndrome

Pediatric Hematology and Oncology
Y SasaharaT Konno

Abstract

We report a case of a 16-month-old Wiskott-Aldrich syndrome (WAS) patient with a WASP gene mutation who received human leukocyte antigen (HLA)-matched, unrelated allogeneic bone marrow transplantation (BMT) followed by an Epstein-Barr virus-associated lymphoproliferative disorder (EB-LPD), diagnosed by clinical findings, polymerase chain reaction detection of the EB virus genome, and spontaneous lymphocyte proliferation of donor cell origin. EB-LPD is one of frequent lethal complications in HLA-mismatched or unrelated BMT in this syndrome. Adoptive immunotherapy with donor leukocyte transfusion, including appropriate numbers of CD3-positive T cells, was effective for the EB-LPD, achieving almost complete recovery 1 year later without any findings of graft-versus-host disease.

Citations

Dec 7, 2002·Critical Reviews in Oncology/hematology·Shigeru Tsuchiya
Sep 4, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Yoji Sasahara
Oct 23, 2004·Best Practice & Research. Clinical Haematology·Helen E HeslopCliona M Rooney
Apr 1, 2004·Expert Opinion on Therapeutic Patents·Astrid MeerbachPeter Wutzler
May 3, 2012·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Morteza Izadi, Saeed Taheri

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