Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient.

Medical Microbiology and Immunology
Andi KrumbholzAndreas Sauerbrei

Abstract

We report the case of a 25-year-old lung and liver transplant recipient who developed respiratory failure. High levels of Epstein-Barr virus (EBV) genome copies were detectable in respiratory tract specimens, while the search for various other viral, bacterial or fungal pathogens remained empty. Post-transplant lymphoproliferative disease was excluded. Due to the rapid progression of respiratory insufficiency, a re-transplantation of the lung was performed. EBV-encoded small RNAs could be demonstrated by in situ hybridization within pneumocytes and lymphocytes of the explanted lung tissue. The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly.

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Citations

May 26, 2016·Current Infectious Disease Reports·Aric L Gregson
Apr 12, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J T SilvaJ M Aguado
Aug 11, 2012·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Frauke MattnerIlka Engelmann
May 29, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Maria ReckziegelAndi Krumbholz
Dec 11, 2020·Respiratory Medicine Case Reports·Muhammad Raphay NiaziMichel Chalhoub

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