PMID: 11918542Mar 29, 2002Paper

Epstein-Barr virus-associated T-cell acute lymphoblastic leukaemia

British Journal of Haematology
Sakura SakajiriKazuo Oshimi

Abstract

Epstein-Barr virus (EBV) is frequently detected in haematological malignancies, including Burkitt's lymphomas/leukaemias, Hodgkin's diseases and non-Hodgkin's lymphomas. However, immature T-cell malignancies associated with EBV have not been reported previously. We report a patient with T-cell acute lymphoblastic leukaemia (T-ALL), whose leukaemic cells had EBV, confirmed by Southern blotting and in situ hybridization. The EBV existed in episomal form and was detected in most leukaemic cells, but not in bystander normal B-cells. The leukaemic cells, massively infiltrated into the liver and spleen, were resistant to chemotherapy. EBV might be associated with tumorigenesis of T-ALL, and characteristic clinical features of the patient.

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Citations

Jan 22, 2010·Indian Journal of Pathology & Microbiology·S SehgalR K Marwaha
Oct 14, 2014·BioMed Research International·A Morales-SánchezE M Fuentes-Pananá
Nov 7, 2016·Mayo Clinic Proceedings·Shilpa PaulElias J Jabbour
Feb 23, 2017·Journal of Medical Virology·Hongzai GuanBing Luo
Oct 10, 2021·International Journal of Cancer. Journal International Du Cancer·Tharcisse MpungaJean-Damien Combes

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