PMID: 9436761Jan 22, 1998Paper

Epstein-Barr virus DNA in the blood of infants, young children, and adults by age and HIV status

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
C D BrandtJ L Sever

Abstract

Polymerase chain reaction (PCR) methodology was used to detect Epstein-Barr virus (EBV) DNA in peripheral blood mononuclear cells (PBMCs) from children and adults whose HIV status (i.e., infected or uninfected) is known. Initial EBV infections especially occurred in children between the ages of 7 and 24 months. EBV-positive children with vertically acquired HIV infection tended to have a detectable blood level of EBV DNA for a period of years, and their EBV DNA blood levels often exceeded 10,000 copies/0.1 ml of blood--hundreds of times higher than levels typically found in EBV-positive, HIV-uninfected children of the same age. EBV DNA was found in PBMCs in 26% of 49 HIV-infected mothers who were sampled during their pregnancy, but the median EBV DNA level in their EBV-positive samples was low--only 50 copies/0.1 ml blood. In limited tests with specimens from children infected with both HIV and EBV, high blood levels of EBV DNA unexpectedly appeared to be associated with decreased blood levels of HIV DNA (p = .063).

References

Oct 1, 1990·Journal of Clinical Microbiology·A TelentiT F Smith
Nov 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C D BrandtJ L Sever

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Citations

Oct 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul D LingJanet S Butel
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Aug 19, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Vivek N AhyaDonald E Tsai
Jan 16, 2007·Experimental and Molecular Pathology·Jing ChenTakashi Yoshiki
Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D CaselliM Aricò

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