Epstein-Barr virus-encoded dUTPase modulates immune function and induces sickness behavior in mice

Journal of Medical Virology
David A PadgettRonald Glaser

Abstract

Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis (IM). In addition, latent infections with EBV are associated with nasopharyngeal carcinoma (NPC) and Burkitt's Lymphoma (BL). Antibodies to several EBV-encoded early antigens (EA) are often observed in patients with NPC and BL, however, the role of EBV-encoded proteins in the etiology of these and other EBV-associated diseases is not completely understood. The EA complex encodes for at least six different viral enzymes including deoxyuridine triphosphate nucleotidohydrolase (dUTPase). dUTPase has recently been shown to modulate activation of human peripheral blood mononuclear cells in vitro (unpublished data). Therefore, these studies were designed to test whether dUTPase would modulate immune function in an in vivo model. Mice were injected with purified EBV dUTPase, and baseline immune function and sickness behaviors were measured. EBV dUTPase treatment inhibited replication of mitogen-stimulated lymphocytes obtained from treated mice. These lymphocytes were also less able to synthesize interferon-gamma after re-stimulation. In addition, treatment with dUTPase induced sickness behaviors. For example, as compared to control animals, dUTPase-treated ani...Continue Reading

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Citations

Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jonathan P Godbout, Ronald Glaser
Jul 23, 2013·Brain, Behavior, and Immunity·Rita A TrammellLinda A Toth
Jan 29, 2011·Brain, Behavior, and Immunity·Melissa D OlivadotiMark R Opp
May 14, 2016·Journal of Behavioral and Brain Science·Taryn G AubrechtRandy J Nelson
Nov 18, 2010·Circulation. Heart Failure·Sitaramesh Emani, Philip F Binkley
Nov 6, 2015·Frontiers in Microbiology·Angela SchwabFatah Kashanchi

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