Epstein-Barr virus in B-cell lymphomas associated with chronic suppurative inflammation

The Journal of Pathology
C Copie-BergmanP G Isaacson

Abstract

Chronic antigenic stimulation is considered to play an important role in neoplastic lymphoid transformation. This paper describes three cases of non-Hodgkin lymphomas (NHLs) associated with long-standing chronic suppuration. Two were primary bone lymphomas associated with long-standing chronic osteomyelitis and one was a primary skin lymphoma associated with chronic venous ulcers with a latent period of 13 years. All were diffuse large B-cell lymphomas, with plasmacytoid differentiation in two cases. Epstein-Barr virus (EBV)-encoded RNAs were demonstrated in virtually all tumour cells in all cases by in situ hybridization. Immunohistochemistry revealed EBV-encoded latent membrane protein (LMP)-1 expression in one case and BZLF1 protein expression in all three cases, whilst the EBV-encoded nuclear antigen (EBNA)-2 was not detected. Kaposi's sarcoma-associated herpesvirus (KSHV) sequences were absent in two cases studied. Our cases show similarities with pyothorax-associated pleural lymphomas reported mainly from Japan and recently from France, which are invariably associated with EBV. These findings suggest a causal effect of EBV in the development of this type of lymphoma complicating long-standing chronic suppuration. Localize...Continue Reading

References

Nov 17, 1979·Lancet·D N PosnettS B Krantz
Dec 15, 1986·Cancer·M L OstrowskiW F Taylor
Jan 1, 1972·Cancer·C FreemanS J Cutler
Feb 2, 1980·Lancet·G LaurentJ Fabre
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Jun 1, 1994·Journal of Clinical Pathology·T C DissP G Isaacson
Jun 1, 1993·The Journal of Pathology·L PanP G Isaacson
Nov 1, 1995·Journal of Clinical Pathology·T C DissP G Isaacson

❮ Previous
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Citations

Aug 8, 2001·International Journal of Experimental Pathology·G NiedobitekH J Delecluse
Jan 12, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Florence LoongJohn K C Chan
Oct 29, 2009·Leukemia & Lymphoma·Alvaro AlencarIzidore S Lossos
Jun 7, 2006·Leukemia & Lymphoma·Apostolia-Maria TsimberidouRazelle Kurzrock
Jul 7, 2009·Hematology/oncology Clinics of North America·Laurence de Leval, Robert Paul Hasserjian
Feb 12, 2008·Surgical Neurology·Jun MasuokaYasuo Sugita
Aug 20, 2003·International Journal of Cancer. Journal International Du Cancer·Ikuko KatoRoy E Shore
Apr 4, 2015·Clinical Case Reports·Kazuhiro HiyamaTakashi Mamiya
Jul 22, 1999·Human Pathology·B F SkinniderD S Viswanatha
Oct 9, 2014·The Journal of Pathology·Martina VockerodtPaul G Murray
May 9, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·J K O'NeillC A Stone
Jun 18, 2015·Journal of Pathology and Translational Medicine·Jung-Woo ChoiYoung-Sik Kim
Nov 2, 2011·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Byong Duk Ye
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Blanca Sanchez-GonzalezAntonio Salar
Apr 11, 2017·American Journal of Clinical Pathology·Yasodha NatkunamElaine S Jaffe
Jan 25, 2012·Inflammatory Bowel Diseases·Harry SokolUNKNOWN CESAME Study Group
Mar 10, 2018·Pathogens·Stefan D DojcinovLeticia Quintanilla-Martinez
May 31, 2003·International Journal of Hematology·Nobumasa HojoShigeru Fujita
Jan 25, 2008·Archives of Orthopaedic and Trauma Surgery·Mark S EskanderKirk Johnson
Jun 13, 2012·Rinshō shinkeigaku = Clinical neurology·Mari HonmaTeiji Yamamoto
Sep 13, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Claire Shannon-LoweAndrew I Bell
Sep 8, 2000·The American Journal of Surgical Pathology·J R GoodladD O Ho-Yen
Jun 13, 2019·Pathology Oncology Research : POR·Amen H ZakyMahmoud Rezk
Sep 25, 2001·Experimental Biology and Medicine·K N PrasadK C Prasad
Oct 18, 2019·ACG Case Reports Journal·Ramy MansourCarolyn Haus
Apr 17, 2017·Allergologia et immunopathologia·A Tak ManeshA Aghamohammadi
Mar 2, 2021·SAGE Open Medical Case Reports·Emam M KhederHussain Al Omar
Mar 17, 2021·Bulletin du cancer·Illias TaziFatima Zahara Lahlimi
Nov 9, 2006·Archives of Pathology & Laboratory Medicine·Francisco VegaL Jeffrey Medeiros
Dec 3, 1999·American Journal of Rhinology·P H HwangD W Kennedy
Dec 1, 2010·Surgical Pathology Clinics·Laurence de Leval

❮ Previous
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