Epstein-Barr virus in inflammatory bowel disease: the spectrum of intestinal lymphoproliferative disorders

Journal of Crohn's & Colitis
Loes H C NissenFrank Hoentjen

Abstract

Inflammatory bowel disease (IBD) patients on thiopurine therapy are at increased risk of Epstein-Barr virus (EBV)-associated lymphomas. This virus is frequently detected in the intestinal mucosa of IBD patients and may cause a wide spectrum of lymphoproliferations similar to post-transplantation lymphoproliferative disorders (PTLDs). We aimed to assess whether histological aberrations aid in predicting EBV presence and to correlate histological assessment and EBV load with disease outcome in IBD. We included all IBD patients from our centre who underwent EBV testing of intestinal biopsies between January 2004 and October 2013. All biopsies were classified according to the WHO PTLD classification and the EBV load was scored per high-power field (HPF). Clinical data were collected from patient charts. Reported clinical outcomes included colectomy, need for chemotherapy and mortality. Our cohort included 58 patients: 28 were EBV-positive and 30 EBV-negative. An atypical infiltrate was seen more frequently in EBV-positive than in EBV-negative patients (57.1 versus 3.3%; p < 0.001). A high EBV load occurred more frequently in EBV-positive patients undergoing colectomy than in EBV-positive patients without colectomy (50.0 versus 10.0...Continue Reading

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Citations

Jun 18, 2019·European Journal of Gastroenterology & Hepatology·Shuang WuYu-Qin Li
Apr 28, 2020·BMJ Open Gastroenterology·Catherine ChoiWeizheng Wang
Oct 10, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rongbei LiuZhinong Jiang
Jul 2, 2019·The American Journal of Surgical Pathology·Jennifer Y JuNadine S Aguilera
Sep 12, 2020·Therapeutic Advances in Gastroenterology·Shu XuYao He
Dec 22, 2017·Journal of Digestive Diseases·Yi ChuJie Liang
Oct 21, 2020·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Jin-Qiu ZhouHua-Tian Gan
Dec 2, 2020·Zeitschrift für Gastroenterologie·Torsten KucharzikUNKNOWN Collaborators:
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Oct 2, 2020·GE Portuguese Journal of Gastroenterology·Maria Do Céu EspinheiraJorge Amil-Dias

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