Abstract
Peripheral lymphocytes from eight patients with congenital immunodeficiency diseases were infected with Epstein-Barr virus (EBV) in an attempt to establish B lymphoblastoid cell lines (LCL). These patients included three boys with congenital agammaglobulinaemia, two girls with hypogammaglobulinaemia, one boy with common variable immunodeficiency, one boy with severe combined immunodeficiency with adenosine deaminase deficiency, and one boy with DiGeorge syndrome. Five of the patients bore no surface immunoglobulins (sIg) on their peripheral lymphocytes. LCL were established from seven of the eight patients. All the LCL established formed rosettes with EAC3 and had the ability to produce cytoplasmic immunoglobulins (cIg) of various classes. Culture supernatants concentrated up to 100-fold developed precipitin bands by Ouchterlony's method with antisera to human Ig in all the established LCL. These results suggested that both sIg-, cIg- and C3+ cells and sIg+, cIg- and C3+ cells might be the target cells for EBV and that sIg-, cIg- and C3+ cells might be the precursor cells of B lymphocytes.
References
Feb 15, 1975·International Journal of Cancer. Journal International Du Cancer·T Katsuki, Y Hinuma
May 1, 1975·Journal of Virology·J Robinson
Jun 15, 1976·International Journal of Cancer. Journal International Du Cancer·E YefenofM B Oldstone
May 5, 1977·Nature·A RosénS Britton
Aug 25, 1977·Nature·D J MossJ H Pope
Dec 1, 1977·Virology·T KatsukiK Kumagai
Jan 1, 1978·Cellular Immunology·L EinhornG Klein
Aug 1, 1978·The Journal of Clinical Investigation·J SchwaberF S Rosen
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J SchwaberF S Rosen
Apr 20, 1978·The New England Journal of Medicine·L B VoglerM D Cooper
Jul 27, 1978·The New England Journal of Medicine·F P SiegalR A Good
Oct 1, 1975·The Journal of Pediatrics·S H Polmar, P A Chase
Jan 1, 1976·Gut·K GyrH Fahrlaender
Jul 1, 1972·The Journal of Experimental Medicine·H B Dickler, H G Kunkel
Dec 30, 1972·Lancet·J Yata, I Tsukimoto
Jan 1, 1973·Clinical Immunology and Immunopathology·J L Preud'HommeM Seligmann
Jan 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·Y Hinuma, J T Grace
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G Miller, M Lipman
Dec 1, 1973·The Journal of Experimental Medicine·M Jondal, G Klein
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·G MillerM Lipman
Dec 1, 1973·The Journal of Clinical Investigation·A EdenV Nussenzweig
Mar 1, 1974·The Journal of Clinical Investigation·H B DicklerW D Terry
Citations
Mar 1, 1985·European Journal of Pediatrics·M MinegishiK Tada
Mar 1, 1984·Journal of Clinical Immunology·D LevittR J Wedgwood
Jul 1, 1983·Journal of Clinical Immunology·P L HaberM D Cooper
Jan 1, 1981·Journal of Inherited Metabolic Disease·S TsuchiyaK Tada
Jul 17, 1982·Lancet·A K SaemundsenR Warnke
Dec 1, 1980·The Journal of Experimental Medicine·S M FuR A Good
Jan 1, 1995·Journal of Medical Genetics·Y OhashiT Konno
Dec 7, 2002·Critical Reviews in Oncology/hematology·Shigeru Tsuchiya
Apr 1, 1990·Human Immunology·V DessiA Nuñez-Roldan
Dec 1, 1981·In Vitro·R H Kennett
Jan 29, 1993·Cell·S TsukadaS Quan
Oct 1, 1983·The Journal of Pediatrics·S TsuchiyaK Tada
Oct 21, 2016·Journal of Periodontology·Pakchisa KhonsuphapAnjalee Vacharaksa
May 24, 1984·Nature·S KatamineY Ono
Jun 1, 1991·Jinrui idengaku zasshi. The Japanese journal of human genetics·M MinegishiT Konno
Jan 1, 1995·Journal of Medical Genetics·J D SteinS H Blanton
Jul 1, 1982·European Journal of Immunology·S PereiraT Platts-Mills
Jul 1, 1988·Immunological Investigations·M E Conley, J M Puck