PMID: 9653094Jul 7, 1998Paper

Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells

The Journal of Experimental Medicine
V N NgoJ G Cyster

Abstract

Movement of T and B lymphocytes through secondary lymphoid tissues is likely to involve multiple cues that help the cells navigate to appropriate compartments. Epstein-Barr virus- induced molecule 1 (EBI-1) ligand chemokine (ELC/MIP3beta) is expressed constitutively within lymphoid tissues and may act as such a guidance cue. Here, we have isolated mouse ELC and characterized its expression pattern and chemotactic properties. ELC is expressed constitutively in dendritic cells within the T cell zone of secondary lymphoid tissues. Recombinant ELC was strongly chemotactic for naive (L-selectinhi) CD4 T cells and for CD8 T cells and weakly attractive for resting B cells and memory (L-selectinlo) CD4 T cells. After activation through the B cell receptor, the chemotactic response of B cells was enhanced. Like its human counterpart, murine ELC stimulated cells transfected with EBI-1/CC chemokine receptor 7 (CCR7). Our findings suggest a central role for ELC in promoting encounters between recirculating T cells and dendritic cells and in the migration of activated B cells into the T zone of secondary lymphoid tissues.

References

May 1, 1976·Cellular Immunology·P Nieuwenhuis, W L Ford
Jan 1, 1992·International Review of Cytology·G Kraal
Jan 1, 1992·Annual Review of Immunology·L J Picker, E C Butcher
Apr 1, 1990·The American Journal of Anatomy·T C Pellas, L Weiss
Oct 13, 1995·Biochemical and Biophysical Research Communications·R BurgstahlerM Lipp
Nov 1, 1995·European Journal of Immunology·A B Lyons, C R Parish
Aug 1, 1995·The Journal of Experimental Medicine·J G Cyster, C C Goodnow
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·T NagasawaT Kishimoto
Jul 1, 1993·The Journal of Experimental Medicine·R F Bargatze, E C Butcher
Feb 1, 1996·International Archives of Allergy and Immunology·K B Bacon, T J Schall
Apr 1, 1996·The Journal of Experimental Medicine·J M Austyn
Sep 1, 1996·The Journal of Experimental Medicine·C C BleulT A Springer
Jan 1, 1997·Annual Review of Immunology·M BaggioliniB Moser
Apr 1, 1997·Current Biology : CB·C C Goodnow, J G Cyster
Apr 1, 1997·Immunological Reviews·R M SteinmanK Inaba
Jun 16, 1997·The Journal of Experimental Medicine·E IngulliM K Jenkins
Jun 1, 1997·Current Biology : CB·C R Mackay
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·M D GunnL T Williams

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Citations

Jun 8, 1999·European Journal of Immunology·F SallustoA Lanzavecchia
Nov 11, 1999·European Journal of Immunology·C García De VinuesaI C MacLennan
Dec 18, 2001·European Journal of Immunology·G BardiP Loetscher
Feb 10, 2000·Springer Seminars in Immunopathology·U SyrbeA Hamann
Jan 13, 2001·Springer Seminars in Immunopathology·H YoneyamaK Matsushima
Dec 29, 2005·Journal of Clinical Immunology·Peter DubskyA Karolina Palucka
Jun 21, 2005·Cytokine & Growth Factor Reviews·Silvano Sozzani
Apr 17, 2013·Cytokine & Growth Factor Reviews·Iain ComerfordShaun R McColl
Feb 13, 2004·Gene·Boris Bartholdy, Patrick Matthias
Mar 25, 2004·Trends in Immunology·Enrico CrivellatoDomenico Ribatti
May 17, 2000·Pharmaceutica acta Helvetiae·S SozzaniA Mantovani
Apr 26, 2003·Mechanisms of Ageing and Development·I GomezB Grubeck-Loebenstein
May 10, 2003·Brain Research. Brain Research Reviews·Paul R WalkerPierre Yves Dietrich
Nov 8, 2001·Experimental Hematology·P BrossartL Kanz
Mar 3, 2001·Current Opinion in Immunology·K M Ansel, J G Cyster
Jan 16, 2002·Current Opinion in Immunology·Andrew D Luster
May 14, 1999·Current Opinion in Immunology·M G McHeyzer-Williams, R Ahmed
Jul 10, 2003·Blood Cells, Molecules & Diseases·Alicia Terando, James J Mulé
Aug 10, 2004·Nature Immunology·Christopher D C AllenJason G Cyster
Sep 12, 2006·Nature Immunology·Rachel S FriedmanMatthew F Krummel
Aug 2, 2005·Nature Reviews. Immunology·Gwendalyn J RandolphMelody A Swartz
Jun 2, 2007·Cell Death and Differentiation·A MorettaL Moretta
Mar 29, 2000·The British Journal of Dermatology·I KimberC E Griffiths
Dec 12, 2001·British Journal of Haematology·H HussonA S Freedman
Sep 13, 2002·Immunology and Cell Biology·Lois L Cavanagh, Ulrich H Von Andrian
Jun 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·David A ZidarRobert J Lefkowitz

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