Epstein-Barr Virus-Infected Plasma Cells Infiltrate Erosive Oral Lichen Planus

Journal of Dental Research
H RaybaudA Doglio

Abstract

Epstein-Barr virus (EBV), in addition to its transforming properties, contributes to the pathogenesis of several inflammatory diseases. Here, we investigated its involvement in oral lichen planus (OLP), a common autoimmune-like disease of unknown etiopathogenesis that can display a malignant potential. EBV-infected cells (EBV+ cells) were sought in a large series of clinically representative OLPs ( n = 99) through in situ hybridization to detect small noncoding EBV-encoded RNAs. Overall, our results demonstrated that EBV was commonly found in OLP (74%), with significantly higher frequency (83%) in the erosive form than in the reticular/keratinized type mild form (58%). Strikingly, many erosive OLPs were massively infiltrated by large numbers of EBV+ cells, which could represent a large part of the inflammatory infiltrate. Moreover, the number of EBV+ cells in each OLP section significantly correlated with local inflammatory parameters (OLP activity, infiltrate depth, infiltrate density), suggesting a direct relationship between EBV infection and inflammatory status. Finally, we characterized the nature of the infiltrated EBV+ cells by performing detailed immunohistochemistry profiles ( n = 21). Surprisingly, nearly all EBV+ cel...Continue Reading

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Citations

Nov 27, 2019·International Journal of Molecular Sciences·Lilit TonoyanAlain Doglio
Aug 4, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sajna AshrafKamran Habib Awan
Mar 14, 2020·Microbial Pathogenesis·Charles V OlivieriSéverine Vincent-Bugnas

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Methods Mentioned

BETA
biopsies
reverse
Profiler
electron microscopy

Software Mentioned

SimpliNano
RT2 Profiler PCR Array Data Analysis

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