Epstein-Barr virus latent membrane 2A (LMP2A) down-regulates telomerase reverse transcriptase (hTERT) in epithelial cell lines

International Journal of Cancer. Journal International Du Cancer
Fu ChenIngemar Ernberg

Abstract

The latent membrane protein (LMP) 2A, one of the membrane-spanning polypeptides encoded by the Epstein-Barr virus (EBV), has been implicated in the maintenance of viral latency and appears to function in part by inhibiting B-cell receptor (BCR) signaling through its ITAM motifs. It has also been suggested that LMP2A is involved in tumorigenesis mediated by EBV. In our study, we determined regulatory effects of LMP2A on the telomerase reverse transcriptase (hTERT) expression. We observed a significant and constant reduction of hTERT mRNA accompanied by decreased telomerase activity in epithelial cells expressing LMP2A. It was further shown that LMP2A inhibited the hTERT promoter activity in transient transfections of both B cells and epithelial cells, and that the ITAM motif was required for this inhibition. Thus LMP2A expression leads to the transcriptional repression of the hTERT gene through specific pathways, which may thereby contribute to the control of EBV-latency.

References

Jan 1, 1977·International Journal of Cancer. Journal International Du Cancer·H Ben-BassatG Klein
Jan 1, 1978·Progress in Experimental Tumor Research·M Andersson-AnvretG Klein
Jan 30, 1976·Science·S H HsuW F Bodmer
Nov 22, 1991·Science·H zur Hausen
Nov 1, 1973·Journal of the National Cancer Institute·D J GiardW P Parks
Jan 1, 1994·Annual Review of Immunology·J C CambierM R Clark
Jan 1, 1993·Annual Review of Cell Biology·A L DeFranco
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·C L MillerR Longnecker
Jan 1, 1996·Progress in Biophysics and Molecular Biology·M Sudol
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K F Norrback, G Roos
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·C W Greider
Aug 11, 1998·Immunity·C FuA C Chan
Aug 10, 1999·Nature·W C HahnR A Weinberg
Aug 31, 2000·Cell·C J Sherr, R A DePinho
May 23, 2002·The Journal of Biological Chemistry·Daeyoup LeeJoonho Choe
Aug 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sheila A StewartRobert A Weinberg
Sep 5, 2002·Microbiology and Molecular Biology Reviews : MMBR·Yu-Sheng CongJerry W Shay

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Citations

Jan 10, 2008·Journal of the National Cancer Institute·Marcia Bellon, Christophe Nicot
Dec 7, 2005·Veterinary Microbiology·U PagniniG Iovane
Feb 4, 2014·Seminars in Cancer Biology·Xinsong ChenMaria G Masucci
Jan 24, 2015·Experimental & Molecular Medicine·Myung-Soo Kang, Elliott Kieff
Jun 20, 2006·European Journal of Immunology·Alexander David Barrow, John Trowsdale
May 1, 2008·Head & Neck·Josephine ChouDavid M Jablons
Feb 28, 2007·Oncogene·S A KamranvarM G Masucci
Oct 1, 2019·Human Vaccines & Immunotherapeutics·Yingchun YanShigen Li
Feb 3, 2021·Cancer Treatment and Research Communications·Ali Salimi-JedaAsghar Abdoli

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