Epstein-Barr virus-latent membrane protein 1 expression has a favorable influence in the outcome of patients with Hodgkin's Disease treated with chemotherapy

Leukemia & Lymphoma
C MontalbanM A Piris

Abstract

The effect of molecular factors in the outcome of Hodgkin's Disease (HD) is being currently studied. In a previous series of HD, including patients treated only with radiotherapy and patients treated with chemotherapy (with or without radiotherapy), we found that a high proliferation index had an adverse influence in overall survival (OS) and in the achievement of a complete remission (CR). Loss of Rb expression also had an adverse prognostic influence in achievement of CR. On the other hand LMP1-EBV expression had a favorable influence for OS. The expression of other molecular factors, p53, bcl2 and CD15 did not show prognostic influence. In the present paper we have studied the effect of these molecular variables in 110 patients, of the previous series who had been treated with chemotherapy. A retrospective study was performed in these 110 patients with HD treated with chemotherapy (ABVD or variants, 62%, or regimes not containing adriamycin, 38%) with or without adjutant radiotherapy, collected at the 11 centers belonging to the Spanish Collaborative Group for the Study of Hodgkin's Disease. The prognostic value of clinical variables and the expression of p53, bcl2, CD15, Rb, LMP 1-EBV and proliferative fraction demonstrated...Continue Reading

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Citations

May 29, 2003·Leukemia & Lymphoma·D BenharrochJ Gopas
Apr 12, 2003·Leukemia & Lymphoma·José VassalloIrene Lorand-Metze
Oct 2, 2004·European Journal of Haematology·Bernhard HolznerRichard Greil
Nov 23, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Veronique DinandRajvir Singh
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander ClaviezWolfgang Dörffel
May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carlos MontalbánUNKNOWN Spanish Hodgkin's Lymphoma Study Group
Sep 28, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Theresa H M KeeganRichard F Ambinder
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arjan DiepstraSibrand Poppema
Jul 13, 2007·São Paulo Medical Journal = Revista Paulista De Medicina·Gevina Silva PinheiroJosé Salvador Rodrigues de Oliveira
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Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomás AlvaroLluis E Pons
Feb 23, 2021·Pathology, Research and Practice·Antonio TravaglinoMassimo Mascolo

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