Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigen

Journal of Virology
Natalie SutkowskiBrigitte T Huber

Abstract

Superantigens are microbial proteins that strongly stimulate T cells. We described previously that the Epstein-Barr virus (EBV) transactivates a superantigen encoded by the human endogenous retrovirus, HERV-K18. We now report that the transactivation is dependent upon the EBV latent cycle proteins. Moreover, LMP-2A is sufficient for induction of HERV-K18 superantigen activity.

References

Feb 14, 1992·Science·A Swain, J M Coffin
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·Y W ChoiP Marrack
Nov 1, 1991·The Journal of Experimental Medicine·D L WoodlandR B Corley
Jan 1, 1991·Annual Review of Immunology·A HermanA M Pullen
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R J MurrayE Kieff
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y W ChoiJ Kappler
Jul 1, 1989·The Journal of General Virology·M J AlldayB E Griffin
Jun 16, 1989·Science·M O'ConnorW Bender
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A CalenderG M Lenoir
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·G MillerM Lipman
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·B KempkesW Hammerschmidt
Dec 1, 1993·Journal of Virology·B TomkinsonE Kieff
Jan 1, 1996·Trends in Microbiology·R Longnecker, C L Miller
Sep 1, 1996·Microbiological Reviews·B T HuberN Sutkowski
Sep 1, 1996·The Journal of Experimental Medicine·N SutkowskiB T Huber
Jun 20, 1998·British Journal of Haematology·S UddinL C Platanias
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y Y WanJ DeGregori
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J ChenW Li
Aug 8, 2001·The Journal of Experimental Medicine·N EngelsJ Wienands
Oct 24, 2001·Seminars in Cancer Biology·A G Eliopoulos, L S Young

❮ Previous
Next ❯

Citations

Mar 12, 2008·The Journal of Experimental Medicine·Andrew G EvansSamuel H Speck
Mar 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Cécile VoissetDavid J Griffiths
Feb 10, 2011·Journal of Translational Medicine·Lucia Lopalco
Feb 12, 2013·Retrovirology·Mamneet Manghera, Renée N Douville
Jul 11, 2006·Retrovirology·Christoffer NellåkerHåkan Karlsson
Aug 21, 2014·Current Neurology and Neuroscience Reports·Mamneet MangheraRenée Douville
Aug 21, 2014·Cellular and Molecular Neurobiology·Alexander EmmerMalte E Kornhuber
Jan 29, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tove Christensen
Aug 30, 2011·Autoimmunity Reviews·David H Dreyfus
Dec 1, 2015·Frontiers in Microbiology·Marie-Josée NadeauRenée N Douville
Oct 23, 2009·Annals of the New York Academy of Sciences·Luis P Villarreal
Jul 19, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·George R YoungGeorge Kassiotis
Nov 23, 2013·American Journal of Physical Anthropology·Alessandro RigaJacopo Moggi-Cecchi
Jun 4, 2014·International Journal of Cancer. Journal International Du Cancer·Ronan F DowneySharon A Glynn
Apr 1, 2014·Cell·Herbert W Virgin
Jan 24, 2015·Experimental & Molecular Medicine·Myung-Soo Kang, Elliott Kieff
Jul 17, 2016·Immunologic Research·David H Dreyfus
May 13, 2017·Médecine sciences : M/S·Julie MedinaHervé Perron
Jun 10, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Albert K TaiBrigitte T Huber
Jan 13, 2005·Blood·Françoise MeylanBernard Conrad
Mar 24, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Rossella TalottaMagdalena Janina Laska
Aug 1, 2020·Reviews in Medical Virology·Zahra SalavatihaSomayeh Jalilvand
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francis C HsiaoBrigitte T Huber
Dec 19, 2015·Minerva pediatrica·Massimiliano BergalloPier L Calvo
Jan 21, 2021·Pharmaceuticals·Victoria GrögerHolger Cynis
Jun 3, 2021·Pharmaceuticals·Karen Giménez-Orenga, Elisa Oltra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.