Epstein-Barr virus reactivation in a patient treated with anti-thymocyte globulin for severe aplastic anemia

American Journal of Hematology
Elisabetta CalistriDaniela Damiani

Abstract

Epstein-Barr virus (EBV) infection and reactivation is an increasing complication in immune deficient patients, particularly after allogeneic hematopoietic stem cell transplantation (HSCT). Therapy with anti-thymocyte globulin (ATG) is associated with higher incidence of EBV-related disease in HSCT patients, but this risk is not documented in patients receiving ATG for severe aplastic anemia (SAA). We describe the case of a patient who developed an EBV infection, with the clinical features of an infectious mononucleosis, after immune suppression with cyclosporine and two courses of ATG for SAA.

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Citations

Sep 23, 2010·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Guruprasad P BhosaleHargovind L Trivedi
Oct 11, 2012·Case Reports in Gastrointestinal Medicine·Hiroko Sugimoto-SekiguchiNaoki Shirafuji
Jun 5, 2015·Future Oncology·Maria Lina TorneselloFranco M Buonaguro
Dec 22, 2017·British Journal of Haematology·Alicia RovóUNKNOWN Severe Aplastic Anaemia Working Party of the EBMT

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