PMID: 6112750Mar 1, 1981Paper

Epstein-Barr virus RNA VII: size and direction of transcription of virus-specified cytoplasmic RNAs in a transformed cell line

Proceedings of the National Academy of Sciences of the United States of America
V van SantenE Kieff

Abstract

At least three separate regions of the Epstein-Barr virus (EBV) genome encode RNA in a cell line that is growth transformed and nonpermissively infected with EBV. Six polyadenylylated cytoplasmic RNAs have been identified from these three regions. An abundant RNA 3.0-3.1 kilobases (kb) long is encoded by DNA of the internal reiteration, IR, and DNA that maps at 25.7-30 megadaltons. A second, abundant, 2.9-kb RNA is primarily encoded by DNA at 110-03 megadaltons but probably has a 3' end to the left of 110 megadaltons. A third, abundant, 3.7-kb RNA is largely encoded by DNA at 63-66 megadaltons and has a 5' end to the left of 63 megadaltons. A less-abundant 1.5-kb RNA is also encoded by IR. The least-abundant polyadenylylated RNAs identified are 2.3 and 2.0 kb. These RNAs have 3' ends mapping of 5-7 megadaltons and 5' ends mapping to the right of 7 megadaltons. The data suggest that there may be two additional polyadenylylated cytoplasmic RNAs, a 3-kb RNA mapping at 26.2-30 megadaltons and a minor RNA mapping at 102-110 megadaltons. An abundant 0.16-kb nonpolyadenylylated RNA is also present in the cytoplasm of IB-4 cells. This RNA precipitates from the cytoplasm in the presence of high concentrations of magnesium, indicating th...Continue Reading

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Citations

Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M Hummel, E Kieff
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M HellerE Kieff
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R A Bhat, B Thimmappaya
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K Hennessy, E Kieff
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E A GroganG Miller
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A HendersonE Kieff
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Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T DambaughE Kieff
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L RymoA Ricksten
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