Apr 1, 1986

Epstein-Barr virus serology in bone marrow transplantations: a one-year retrospective study with detection of EBV IgM-VCA-specific antibodies

Journal of Medical Virology
F MorinetY Perol


The specific antibody response to Epstein-Barr virus (EBV) antigens of 41 bone marrow transplant recipients with leukemia or aplastic anemia was examined retrospectively by immunofluorescence test (IF) over 1 year. We observed high titers (greater than 640) of IgG-viral capsid antigen (VCA) with emergence of IgG-early antigen (EA) and frequent absence or low levels of Epstein-Barr nuclear antigen (EBNA) antibodies. After absorption to remove rheumatoid factor (RF), five of the 41 recipients had IgM-VCA antibody to EBV, which appeared between weeks 26 and 48 after BMT and persisted for 1-4 months. No heterophil antibodies were detected in these sera, and none of the five recipients had a history of infectious mononucleosis.

  • References15
  • Citations2
  • References15
  • Citations2


Mentioned in this Paper

Epstein-Barr Virus Serology
Immunofluorescence Assay
Infectious Mononucleosis
Aplastic Anemia
Antibodies, Viral
Bone Marrow
Antibody Test; Epstein-Barr (EB) Virus, Nuclear Antigen (EBNA)
Epstein-Barr viral capsid antigen
Phosphoglycerate Dehydrogenase Activity
15TD3 antigen

About this Paper

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

International Journal of Cancer. Journal International Du Cancer
B LangeG Henle
International Journal of Cancer. Journal International Du Cancer
J L SullivanF L Johnson
Proceedings of the National Academy of Sciences of the United States of America
A RickstenL Rymo
© 2020 Meta ULC. All rights reserved