Apr 1, 1986

Epstein-Barr virus serology in bone marrow transplantations: a one-year retrospective study with detection of EBV IgM-VCA-specific antibodies

Journal of Medical Virology
F MorinetY Perol

Abstract

The specific antibody response to Epstein-Barr virus (EBV) antigens of 41 bone marrow transplant recipients with leukemia or aplastic anemia was examined retrospectively by immunofluorescence test (IF) over 1 year. We observed high titers (greater than 640) of IgG-viral capsid antigen (VCA) with emergence of IgG-early antigen (EA) and frequent absence or low levels of Epstein-Barr nuclear antigen (EBNA) antibodies. After absorption to remove rheumatoid factor (RF), five of the 41 recipients had IgM-VCA antibody to EBV, which appeared between weeks 26 and 48 after BMT and persisted for 1-4 months. No heterophil antibodies were detected in these sera, and none of the five recipients had a history of infectious mononucleosis.

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Citations

Mentioned in this Paper

Epstein-Barr Virus Serology
Immunofluorescence Assay
Infectious Mononucleosis
Aplastic Anemia
Antibodies, Viral
Bone Marrow
Antibody Test; Epstein-Barr (EB) Virus, Nuclear Antigen (EBNA)
Epstein-Barr viral capsid antigen
Phosphoglycerate Dehydrogenase Activity
15TD3 antigen

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