Epstein-Barr virus strain type and latent membrane protein 1 gene deletions in lymphomas in patients with rheumatic diseases

Arthritis and Rheumatism
Y NatkunamO W Kamel

Abstract

Recent studies have shown that immunomodulatory therapy for the treatment of rheumatic diseases can be associated with the development of Epstein-Barr virus (EBV)-associated lymphoproliferative disorders. The present study was undertaken to determine the strain type of EBV in lymphoproliferative disorders that occur in patients with rheumatic disease and to investigate EBV latent membrane protein 1 (LMP-1) gene deletions that occur in these lymphoproliferative disorders. Ten EBV-associated lymphoid neoplasms in patients with rheumatoid arthritis or dermatomyositis were analyzed by polymerase chain reaction to determine EBV strain type and to investigate for the presence of a previously characterized 30-basepair deletion in the LMP-1 gene. The results indicated that lymphoproliferative disorders in these patients can harbor EBV strain type A or B, with a predominance of type A infection (80%). It was also shown that both wild-type and mutated LMP-1 genes can be found in these neoplasms, with the deleted form of the LMP-1 gene occurring in one-third of cases in this series. LMP-1 deletions associated with certain aggressive lymphoid neoplasms are not required for the genesis of lymphoproliferative disorders in patients with rheum...Continue Reading

References

Sep 1, 1990·The Journal of Infectious Diseases·T B SculleyD A Cooper
Oct 1, 1994·The Journal of General Virology·W E MillerN Raab-Traub
Jan 1, 1993·Acta Haematologica·H KnechtB F Odermatt
Apr 1, 1996·Arthritis and Rheumatism·M van de RijnO W Kamel
Jun 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E SalloumJ Murren

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Citations

Jul 27, 1999·Annals of the Rheumatic Diseases·A Perl
Nov 11, 2019·Pathology·Mario L Marques-PiubelliRoberto N Miranda
Jul 13, 2001·Infectious Disease Clinics of North America·E BouzaP Muñoz

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