PMID: 9537582Apr 16, 1998Paper

Epstein-Barr virus strain variation in nasopharyngeal carcinoma from the endemic and non-endemic regions of China

International Journal of Cancer. Journal International Du Cancer
N S SungN Raab-Traub

Abstract

Nasopharyngeal carcinoma (NPC) occurs with a striking geographic incidence and is endemic in parts of southern China, where it is the major cause of cancer death. Epstein-Barr virus (EBV) is detected in all cells of the majority of NPC cases regardless of geographic origin. A small subset of EBV genes is expressed in NPC, including the latent membrane protein (LMP-1). LMP-1 is essential for transformation of B lymphocytes and is considered to be the EBV oncogene. This analysis of the DNA sequence variation within the LMP-1 gene reveals a consensus sequence for a strain, denoted China1, which predominates in East Asia where NPC is endemic. The China1 strain is characterized by nucleotide changes at 13 loci in the amino terminal portion of the LMP-1 gene when compared with the B95-8 prototype, including a point mutation resulting in the loss of an Xho1 restriction site. This strain was present in 9 of 15 NPC biopsy specimens from the endemic region and in 7 of 13 from northern China, where NPC is non-endemic. A second strain, China2, was detected in 4 of 15 endemic isolates and in 2 of 13 non-endemic isolates; this strain was characterized by a cluster of 5 nucleotide changes in the amino terminal portion of LMP-1 in addition to ...Continue Reading

References

May 1, 1988·The Journal of General Virology·L S YoungA B Rickinson
Oct 15, 1986·Virology·U ZimberU Schneider
Sep 1, 1995·Journal of Molecular Evolution·K Mohammad-AliF Galibert
Jan 1, 1995·Molecular Biology and Evolution·J Adachi, M Hasegawa
Oct 1, 1994·The Journal of General Virology·W E MillerN Raab-Traub
May 29, 1996·International Journal of Cancer. Journal International Du Cancer·S T CheungD P Huang

❮ Previous
Next ❯

Citations

Jan 15, 2003·Journal of Virology·Diane Sitki-GreenNancy Raab-Traub
Jan 11, 2000·Journal of Virology·R S MidgleyS P Lee
Dec 25, 2003·Journal of Virology·Rachel H EdwardsNancy Raab-Traub
Jan 9, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Danai TiwawechTakafumi Ishida
May 16, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Elisabeth Puchhammer-Stöckl, Irene Görzer
Apr 30, 2010·The Journal of General Virology·Vannarat SaechanTakafumi Ishida
Mar 15, 2015·Seminars in Diagnostic Pathology·Fredrik Petersson
Jul 20, 2016·Journal of Medical Virology·Marco NevesHugo Sousa
Aug 14, 2010·Acta Biochimica Et Biophysica Sinica·Shanli ZhuLifang Zhang
Nov 25, 2006·Cancer Immunology, Immunotherapy : CII·Maurizio ProvenzanoFrancesco M Marincola
Jan 1, 2012·Pathogens·Stelios Tzellos, Paul J Farrell
Mar 22, 2018·Cancers·Kathy H Y ShairVaughn S Cooper
May 13, 2003·International Journal of Cancer. Journal International Du Cancer·Kai Yu JenTakashi Saku
Sep 2, 2003·International Journal of Cancer. Journal International Du Cancer·Lian-hua KimSibrand Poppema
Dec 31, 1998·Springer Seminars in Immunopathology·M RoweL S Young
Mar 27, 2001·International Journal of Cancer. Journal International Du Cancer·S HenryB Mariame
Mar 30, 2000·International Journal of Cancer. Journal International Du Cancer·N S SungN Raab-Traub

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.