Equilibrium and kinetic studies on the interaction of tetracyclines with calcium and magnesium

Biophysical Chemistry
S R Martin

Abstract

The interaction of Ca2+ and Mg2+ with three Tetracycline antibiotics (tetracycline, chlorotetracycline, and oxytetracycline) has been investigated. Spectrophotometric measurements have been used to determine the apparent association constant for this interaction as a function of pH. It is shown that the results are consistent with a model in which the metal ion can form complexes with both the fully-deprotonated and mono-protonated forms of the Tetracycline. The temperature-jump relaxation method has been used to measure the kinetics of formation of the complexes of Mg2+ with the Tetracyclines. The results are compared with those of previous studies of Mg2+ complex formation reactions and it is shown that the data is consistent with the normal dissociative model. A possible role for metal ion chelation in the mechanism of antibacterial action of the Tetracyclines is discussed.

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Citations

Nov 21, 2015·Bulletin of Environmental Contamination and Toxicology·Matthias HundtRalf Schulz
Jan 9, 2013·Journal of Environmental Management·Eman M ElsayedRamanbhai M Patel
Dec 18, 2014·Biophysical Journal·Andreas J ReussJosef Wachtveitl
Jun 2, 2007·Biophysical Chemistry·Lihua JinAlexander Han
Dec 1, 1999·Pharmaceutical Development and Technology·S TongareeR I Poust
Jul 10, 2019·Veterinary Medicine and Science·Julieta M DecundoAlejandro L Soraci
Oct 21, 2009·Inorganic Chemistry·Melanie R HauserHåkon Hope
Jan 31, 2004·Environmental Science & Technology·Raquel A FigueroaAllison A MacKay

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