PMID: 11607175Apr 15, 1991Paper

Equilibrium compositions of solutions of biochemical species and heats of biochemical reactions

Proceedings of the National Academy of Sciences of the United States of America
Robert A Alberty

Abstract

Equilibrium compositions of solutions of biochemical species can be calculated by use of general equilibrium computer programs that minimize the Gibbs energy. The standard Gibbs energies of formation and standard enthalpies of formation of the species in a biochemical system can be calculated by Gaussian reduction of the augmented transpose of the stoichiometric number matrix for the system. The conservation matrix, which is also needed for the calculation of the equilibrium composition, can be obtained in two ways. The hydrolysis of adenosine 5'-triphosphate in solutions containing magnesium ions can be treated by considering 17 species. The equilibrium composition and enthalpy are calculated before and after adding ATPase. This makes it possible to calculate DeltapH, DeltapMg, and the heat of reaction when ATPase is added.

Citations

Dec 6, 2001·Bulletin of Mathematical Biology·J S OliveiraD A Dixon
Jul 20, 1994·Biochimica Et Biophysica Acta·R A Alberty
Aug 13, 1998·Biophysical Chemistry·N KishoreE W Miles
Jan 25, 2003·European Journal of Biochemistry·Hong QianShou-dan Liang
Apr 5, 2003·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Joseph S OliveiraMary L Chandler
Dec 21, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Daniel A Beard
Jun 25, 2002·Biophysical Journal·Daniel A BeardHong Qian
Oct 28, 2004·American Journal of Physiology. Endocrinology and Metabolism·Daniel A Beard, Hong Qian

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